EAPP Activators refer to a class of chemical compounds that are designed to boost the expression or activity of E2F-associated phosphoprotein (EAPP), a protein encoded by the C6orf166 gene in humans. This protein is a critical participant in the cell cycle regulation, acting as a link between the E2F transcription factor and the cyclin A-associated kinase, contributing to the transition from the G1 to the S phase of the cell cycle. Therefore, EAPP activators, through their inherent chemistry and mechanisms, can influence these fundamental cellular processes by modulating the expression or functionality of EAPP.
EAPP activators can operate in a variety of ways. Some may interact directly with the EAPP protein or its encoding gene, boosting its expression or its ability to interact with other proteins. Others might function by targeting the signaling pathways that regulate EAPP's expression or activity, thereby enhancing its role in the cell cycle. The precise mechanisms of action for these activators can vary widely, as can their impact on the cell cycle, depending on numerous factors such as the specific compound, the cell type, and the cellular context. Despite these variations, EAPP activators represent a valuable tool for exploring the intricate processes of cell cycle regulation and the role of EAPP within that context. These compounds are instrumental in advancing our understanding of cellular biology and the complex network of interactions that govern cell proliferation and cycle progression.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $84.00 $166.00 $302.00 $2091.00 $5212.00 $16657.00 | 51 | |
Rottlerin is known to inhibit the protein kinase C delta (PKCδ) which may impact cell cycle regulation and potentially influence EAPP expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can regulate gene expression through modulation of transcription factors like NF-κB, which may indirectly affect EAPP expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can impact cell cycle regulation and potentially influence EAPP expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may alter the expression of cell cycle-related genes, possibly including EAPP, through its action on various signaling pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can influence the cell cycle and apoptosis through various pathways, potentially impacting EAPP expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide affects the cell cycle regulation by inhibiting topoisomerase II, potentially influencing EAPP expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can modulate gene expression in the cell cycle, potentially affecting EAPP expression. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel affects cell cycle progression by stabilizing microtubules, potentially influencing EAPP expression. | ||||||