E430018J23Rik Activators
Zfp764l1, a zinc finger protein, plays a crucial role in the regulation of transcription by RNA polymerase II. Predicted to possess DNA-binding transcription factor activity, Zfp764l1 is involved in the cis-regulatory region sequence-specific DNA binding, emphasizing its importance in orchestrating precise transcriptional responses. The intricate regulatory network governing Zfp764l1 is tightly associated with epigenetic modifications and chromatin dynamics.
Activation of Zfp764l1 can be achieved through various chemical modulators that influence its regulatory elements. Histone deacetylase inhibitors, such as Trichostatin A and SAHA, enhance Zfp764l1 activity by promoting histone acetylation, facilitating an open chromatin structure favorable for Zfp764l1 binding to target DNA sequences. DNA methyltransferase inhibitors like 5-Aza-2'-deoxycytidine relieve transcriptional repression by demethylating Zfp764l1 promoter regions, ensuring increased expression. Furthermore, bromodomain inhibitors like JQ1 disrupt interactions between Zfp764l1 and acetylated histones, modulating its transcriptional role. The general mechanisms of Zfp764l1 activation involve a delicate interplay of epigenetic regulation and chromatin dynamics. The identified chemical activators impact specific pathways to influence Zfp764l1, ultimately regulating RNA polymerase II-dependent transcription. Understanding these mechanisms provides insights into strategies for conditions where Zfp764l1-mediated transcriptional regulation may be implicated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, enhances Zfp764l1 by preventing histone deacetylation, promoting an open chromatin structure, and facilitating the binding of Zfp764l1 to its target DNA sequences, thus upregulating transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, demethylates Zfp764l1 promoter regions, relieving transcriptional repression. This leads to increased Zfp764l1 expression and activity in regulating RNA polymerase II-dependent transcription. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a bromodomain inhibitor, disrupts the interaction between Zfp764l1 and acetylated histones, modulating transcription. This interaction interference results in the activation of Zfp764l1 and subsequent regulation of RNA polymerase II-mediated transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol, activates Zfp764l1 by inhibiting histone deacetylases and promoting an open chromatin structure. This facilitates Zfp764l1 binding to target DNA sequences, enhancing its role in RNA polymerase II-dependent transcription. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid activates Zfp764l1 through modulation of chromatin accessibility. By influencing chromatin structure, betulinic acid facilitates Zfp764l1 binding to cis-regulatory regions, thereby promoting RNA polymerase II-dependent transcription. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EPZ-6438, a histone methyltransferase inhibitor, regulates Zfp764l1 by preventing histone methylation, influencing chromatin conformation. This leads to increased Zfp764l1 activity in the context of RNA polymerase II-dependent transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA, a histone deacetylase inhibitor, activates Zfp764l1 by promoting histone acetylation. This epigenetic modification facilitates Zfp764l1 binding to DNA, enhancing its role in the positive regulation of RNA polymerase II-dependent transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates Zfp764l1 by promoting SIRT1 activity, affecting chromatin structure and enhancing Zfp764l1 binding to cis-regulatory regions. This results in increased RNA polymerase II-dependent transcriptional activity of Zfp764l1. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $36.00 $88.00 $220.00 $436.00 | 8 | |
L-Mimosine activates Zfp764l1 through modulation of iron-dependent dioxygenases. By influencing the cellular iron pool, L-mimosine enhances Zfp764l1 activity, affecting RNA polymerase II-dependent transcription of target genes. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
EPZ004777, a histone methyltransferase inhibitor, regulates Zfp764l1 by inhibiting specific histone methylation patterns. This influences chromatin conformation, enhancing Zfp764l1 binding to cis-regulatory regions and promoting RNA polymerase II-dependent transcription. | ||||||