E2F-2 Inhibitors
E2F-2 inhibitors belong to a class of chemical compounds designed to specifically interact with and modulate the activity of E2F-2, a member of the E2F family of transcription factors. E2F-2 plays a crucial role in the regulation of the cell cycle, particularly in the transition from the G1 to the S phase, where it is involved in the expression of genes necessary for DNA synthesis. The E2F family consists of several members, each with unique and overlapping functions, but E2F-2 has been identified as having a significant impact on cell proliferation due to its ability to drive the expression of genes necessary for DNA replication. Inhibitors of E2F-2 function by interfering with the protein's ability to bind to DNA, its interaction with other regulatory proteins, or its stability and degradation within the cell. The design of these inhibitors often involves the targeting of specific domains within the E2F-2 protein, such as the DNA-binding domain or the dimerization domain that it uses to form complexes with other proteins.
The development of E2F-2 inhibitors necessitates a profound understanding of the protein's structure-function relationship, as well as the intricate network of interactions it participates in within the cell. These inhibitors are typically small molecules that have been optimized through various medicinal chemistry strategies to enhance their specificity, affinity, and cellular permeability. The aim is to achieve maximal modulation of E2F-2 activity while minimizing off-target effects that could lead to unwanted cellular responses. The specificity of these inhibitors is of paramount importance, given the existence of other E2F family members and the need to selectively modulate E2F-2 without affecting the function of other closely related proteins. Furthermore, due to the central role of E2F-2 in cell cycle regulation, these inhibitors must be finely tuned to achieve the desired level of modulation, as both under- and over-inhibition could have profound effects on cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenol from turmeric, has been shown to downregulate E2F-2 expression by modulating signaling pathways and epigenetic mechanisms, contributing to its anti-proliferative effects. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane may inhibit E2F-2 expression by inducing phase II detoxification enzymes and modulating epigenetic changes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid present in many fruits and vegetables, has been observed to downregulate E2F-2 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, the major catechin in green tea, has been shown to suppress E2F-2 expression through the modulation of various signaling pathways, including the MAPK and NF-κB pathways. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
DIM, a compound found in the digestion of indole-3-carbinol found in cruciferous vegetables, can inhibit E2F-2 expression, potentially through its ability to modulate estrogen metabolism and signal transduction pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone found in soybeans, has potential to downregulate E2F-2 expression by influencing epigenetic modifications and signaling pathways, such as the PI3K/Akt pathway. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Derived from milk thistle, silibinin has been shown to inhibit E2F-2 expression, potentially through its antioxidant properties and ability to modulate cell cycle regulators. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Found in berries and nuts, ellagic acid may suppress E2F-2 expression by modulating various signaling pathways and inducing cell cycle arrest. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
I3C, found in cruciferous vegetables, has been shown to inhibit E2F-2 expression, potentially through its ability to modulate estrogen metabolism and detoxification enzymes. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Extracted from various plants, berberine has the potential to downregulate E2F-2 expression by influencing various signaling pathways and epigenetic mechanisms. | ||||||