Date published: 2026-3-20

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E2F-2 Activators

E2F-2 activators represent a class of chemical compounds that play a crucial role in regulating cell cycle progression and gene expression. To understand E2F-2 activators, it's essential to delve into the underlying molecular mechanisms. E2F-2 itself is a transcription factor that belongs to the E2F family, known for its involvement in controlling the cell cycle. E2F-2 activators are substances or molecules that facilitate the activation or upregulation of E2F-2, thereby influencing downstream cellular processes.

At the heart of E2F-2 activators' function is their ability to modulate the transcriptional activity of E2F-2. E2F-2 is primarily responsible for regulating genes involved in DNA replication and cell cycle progression, making it a key player in maintaining proper cell division. When E2F-2 activators bind to E2F-2 or its associated regulatory elements, they can enhance E2F-2's transcriptional activity, leading to increased expression of its target genes. This, in turn, can drive cell cycle progression by promoting DNA synthesis and cell proliferation. The activation of E2F-2 by these compounds is tightly regulated and serves as a fundamental mechanism to ensure proper cellular growth and development. Understanding the precise role and regulation of E2F-2 activators in the context of cell biology is essential for unraveling the complex web of molecular events governing cell cycle control and gene expression. These compounds, by modulating E2F-2 activity, contribute to our understanding of the intricate regulatory networks that govern cell fate and growth, shedding light on the fundamental processes that underlie development and tissue homeostasis.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

This polyphenol compound may upregulate E2F-2 by activating sirtuin 1 (SIRT1), which can lead to cell cycle progression and is also involved in various cellular processes including aging, inflammation, and energy metabolism.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

A derivative of vitamin A, retinoic acid may influence E2F-2 expression through retinoid receptors, affecting cell differentiation, proliferation, and apoptosis.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$218.00
$322.00
$426.00
7
(1)

As a DNA methylation inhibitor, this compound may induce E2F-2 expression by demethylating its promoter region, leading to the activation of its transcription.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$133.00
$275.00
37
(2)

A histone deacetylase inhibitor, vorinostat may increase E2F-2 expression by altering chromatin structure and enhancing the accessibility of transcriptional machinery to the E2F-2 promoter.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

Another histone deacetylase inhibitor, trichostatin A can potentially upregulate E2F-2 by modifying chromatin structure, promoting gene transcription.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Utilized in various biological research contexts, lithium chloride may modulate E2F-2 expression through pathways related to cell survival, proliferation, and neuroprotection.

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$172.00
$305.00
66
(3)

This antibiotic inhibits N-linked glycosylation and may induce E2F-2 expression as a cellular response to endoplasmic reticulum stress, potentially affecting protein folding and cellular homeostasis.