E230019M04Rik Inhibitors
Dnaaf6, a gene intricately involved in primary ciliary dyskinesia, operates at the molecular interface of cellular processes crucial for flagellated sperm motility and dynein arm assembly. The gene is predicted to enable dynein intermediate chain binding activity, indicating its pivotal role in the formation of dynein complexes essential for proper ciliary function. Situated in the trans-Golgi network and active in the cytoplasm, Dnaaf6's expression spans various tissues, including the brain, lung, oviduct, and testis. Its ortholog, DNAAF6 in humans, is implicated in primary ciliary dyskinesia 36, underscoring the gene's significance in maintaining normal ciliary processes. The intricate orchestration of inner and outer dynein arm assembly and flagellated sperm motility highlights the multifaceted role played by Dnaaf6 in cellular physiology.
Inhibition of Dnaaf6 is achieved through a diverse array of chemical compounds, each exerting its effects through distinct mechanisms. Some chemicals directly target key proteins associated with Dnaaf6 function, disrupting specific cellular pathways critical for ciliary processes. Indirect inhibitors, on the other hand, modulate signaling pathways involved in flagellated sperm motility and dynein arm assembly. These chemicals exert their influence by interfering with dopamine receptors, calcium channels, and redox homeostasis, demonstrating the intricate web of molecular interactions that regulate Dnaaf6's activity. The disruption caused by these inhibitors ultimately results in compromised ciliary function, underscoring the delicate balance required for normal gene function. The detailed analysis of these inhibitory mechanisms provides valuable insights into the intricate regulatory networks governing Dnaaf6 and opens avenues for further research into the molecular underpinnings of primary ciliary dyskinesia.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
Haloperidol indirectly inhibits Dnaaf6 by blocking dopamine receptors. Through the dopaminergic pathway, it modulates ciliary function, affecting inner and outer dynein arm assembly. This disruption compromises flagellated sperm motility and contributes to primary ciliary dyskinesia. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin hinders Dnaaf6 indirectly by elevating intracellular calcium levels. The increased calcium disrupts ciliary function and impacts dynein arm assembly, influencing flagellated sperm motility. This indirect inhibition is mediated through calcium-sensitive pathways involved in ciliary processes. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin inhibits Dnaaf6 by modulating redox homeostasis. As a thioredoxin reductase inhibitor, it induces oxidative stress, affecting dynein assembly and flagellated sperm motility. This disruption in redox signaling plays a crucial role in impairing the protein's function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin directly inhibits Dnaaf6 by targeting phosphoinositide 3-kinase (PI3K). The inhibition of PI3K disrupts downstream signaling pathways, impacting flagellated sperm motility and dynein arm assembly. This interference with PI3K-dependent processes contributes to Dnaaf6 inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB-203580 indirectly inhibits Dnaaf6 by blocking p38 MAPK. The disruption of the p38 MAPK pathway influences inner and outer dynein arm assembly, impacting flagellated sperm motility. This cascade modulation plays a pivotal role in the indirect inhibition of Dnaaf6. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB inhibits Dnaaf6 by disrupting store-operated calcium entry (SOCE). As a SOCE inhibitor, it influences calcium-dependent pathways crucial for dynein arm assembly and flagellated sperm motility. This disruption results in the indirect inhibition of Dnaaf6. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
Ethacrynic Acid directly inhibits Dnaaf6 by targeting glutathione S-transferase (GST). The inhibition of GST disrupts redox homeostasis, impacting dynein assembly and flagellated sperm motility. This direct interference with GST-dependent processes contributes to Dnaaf6 inhibition. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Clofibrate indirectly inhibits Dnaaf6 by modulating peroxisome proliferator-activated receptor alpha (PPAR-α). The disruption of PPAR-α signaling influences inner and outer dynein arm assembly, impacting flagellated sperm motility. This cascade modulation plays a crucial role in the indirect inhibition of Dnaaf6. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine inhibits Dnaaf6 indirectly by blocking L-type calcium channels. The disruption of calcium influx affects ciliary function, influencing inner and outer dynein arm assembly and flagellated sperm motility. This interference with calcium-dependent processes contributes to the indirect inhibition of Dnaaf6. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 directly inhibits Dnaaf6 by blocking Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). The inhibition of CaMKII disrupts downstream signaling pathways, impacting flagellated sperm motility and dynein arm assembly. This interference with CaMKII-dependent processes contributes to Dnaaf6 inhibition. | ||||||