Dynein IC2 Inhibitors
Dynein IC2 inhibitors belong to a specific class of chemical compounds that play a crucial role in the regulation of intracellular transport within eukaryotic cells. Dyneins are motor proteins that move along microtubules, which are essential components of the cytoskeleton, to transport various cellular cargoes. The dynein IC2 (Intermediate Chain 2) is a subunit of the dynein motor complex, and inhibitors targeting this protein have garnered significant attention in the field of cell biology and drug discovery. These inhibitors are designed to interfere with the function of dynein IC2, thereby disrupting intracellular transport processes.
Dynein IC2 inhibitors are characterized by their ability to bind to dynein IC2 and modulate its activity. By doing so, they can perturb the motor function of dynein complexes, leading to alterations in the transport of organelles, vesicles, and other cellular components. This disruption of intracellular transport can have profound effects on various cellular processes, including the maintenance of cell structure, cell division, and the distribution of essential molecules within the cell. Researchers have been exploring the potential applications of dynein IC2 inhibitors to gain insights into the fundamental mechanisms of cellular transport and to develop tools for manipulating cellular processes in a controlled and specific manner.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is known to inhibit protein synthesis in eukaryotic organisms by interfering with the translocation step in protein synthesis. This could lead to a reduction in the expression of Dynein IC2. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and prevents the initiation of RNA synthesis, which could lead to a decrease in the mRNA levels of Dynein IC2, subsequently reducing its protein expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which plays a key role in regulating protein synthesis. By inhibiting this pathway, Rapamycin could reduce the expression of Dynein IC2. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $352.00 $566.00 $1331.00 $2453.00 | ||
Emetine inhibits protein synthesis in eukaryotic cells by blocking the elongation phase of translation. This could result in decreased expression of Dynein IC2. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Puromycin causes premature chain termination during protein synthesis. This could disrupt the synthesis of Dynein IC2 and reduce its expression. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol inhibits protein synthesis in bacteria, and at high concentrations, it may also affect eukaryotic cells. This could potentially reduce Dynein IC2 expression. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin inhibits protein synthesis by interfering with the peptidyl transferase activity of the ribosome. This could lead to decreased expression of Dynein IC2. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
Tetracycline inhibits protein synthesis by preventing the attachment of aminoacyl-tRNA to the ribosome. This could reduce the expression of Dynein IC2. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
Erythromycin inhibits protein synthesis by binding to the 50S ribosomal subunit. While it primarily affects bacterial cells, at high concentrations, it may also reduce protein expression in eukaryotic cells, including Dynein IC2. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin inhibits bacterial RNA polymerase, and at high concentrations, it may also affect eukaryotic RNA polymerase, potentially reducing the expression of Dynein IC2. | ||||||