DUX1 Activators
DUX1 activators encompass a collection of chemicals that might influence the activity of DUX1, a protein associated with muscle differentiation and epigenetic regulation. Forskolin, a molecule elevating cAMP levels, demonstrates how intracellular second messengers can shape the behavior of proteins involved in muscle cell differentiation. Epigenetic modulation provides another avenue through which DUX1 might be influenced. 5-Azacytidine and Trichostatin A, both known to restructure the epigenetic landscape, show how methylation and histone acetylation can be potential indirect influencers on DUX1's activity.
The spectrum of muscle cell differentiation is further captured by agents such as Retinoic acid and Dexamethasone, highlighting the intricate cellular decisions that can indirectly mold DUX1's behavior. Similarly, the role of intracellular signaling is illuminated with compounds like Myricetin and Rapamycin, each targeting specific pathways that feed into the muscle differentiation matrix. Additionally, the intricacies of protein behavior, stabilization, and their modulation via proteasome inhibition can be seen with MG132. With the TGF-β pathway playing a role in muscle cell behavior, inhibitors like SB431542 present another avenue of potential influence on DUX1.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Elevates cellular cAMP levels, which can activate several cellular pathways involved in muscle differentiation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Acts as a DNA methyltransferase inhibitor and can influence epigenetic regulation, possibly affecting DUX1 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor, it can change chromatin structure and potentially influence DUX1 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Influences cellular differentiation, particularly in muscle cells, which can have downstream effects on proteins like DUX1. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Modulates various gene expression patterns which can indirectly influence muscle differentiation proteins. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $95.00 $184.00 $255.00 $500.00 $1002.00 | 3 | |
Known as a kinase inhibitor, it can influence pathways related to muscle differentiation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Acts as a histone deacetylase inhibitor, influencing epigenetic changes that might affect DUX1 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting mTOR, it can influence cellular growth and metabolism in muscle cells, potentially impacting DUX1. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
By modulating intracellular calcium levels, it can activate signaling cascades that are crucial for muscle cell functions, potentially influencing DUX1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that can stabilize proteins and potentially influence DUX1's activity or its regulators. | ||||||