DUSP5 Activators
The class of chemicals known as DUSP5 Activators comprises a diverse array of compounds that exert their influence on the dephosphorylating enzyme DUSP5, regulating its activity within the intricate network of cellular signaling pathways. These activators showcase the interconnectedness of various cellular processes and signaling cascades, emphasizing the multifaceted nature of DUSP5 modulation. One prominent subgroup within this class includes polyphenols such as Resveratrol and Fisetin. Resveratrol activates DUSP5 through the SIRT1/AMPK pathway, showcasing the integration of DUSP5 into cellular energy regulation. On the other hand, Fisetin indirectly activates DUSP5 by inhibiting the PI3K/Akt pathway, revealing the crossroads between DUSP5 and growth factor signaling. Another subgroup involves terpenoids like Ursolic Acid and Oleanolic Acid, which modulate DUSP5 through the mTOR and PI3K/Akt pathways, respectively, underscoring the role of DUSP5 in cellular growth and survival.
Flavonoids such as Quercetin and Genistein form another significant cluster, with Quercetin acting as an indirect activator through JNK pathway inhibition and Genistein through c-Jun pathway suppression. These examples highlight the intricate crosstalk between DUSP5 and inflammatory or hormonal signaling pathways. Additionally, stilbenes like Piceatannol and Betulinic Acid, as well as catechins like EGCG, contribute to the class by modulating DUSP5 through the inhibition of stress-responsive signaling pathways. Furthermore, triterpenoids, including Betulinic Acid and Oleanolic Acid, shed light on the interplay between DUSP5 and developmental signaling pathways such as Wnt and growth factor signaling. Lastly, bioactive compounds like Honokiol showcase the connection between DUSP5 and immune-related signaling pathways, specifically TLR4/NF-κB. In summary, the DUSP5 Activators class exemplifies the diverse strategies employed by various chemicals to modulate DUSP5 activity. These compounds showcase the intricate regulatory mechanisms governing DUSP5 within the cellular landscape, emphasizing its pivotal role in integrating signals from different pathways and cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound found in red grapes, activates DUSP5 through the SIRT1/AMPK pathway. It enhances SIRT1 deacetylase activity, leading to AMPK activation, which subsequently upregulates DUSP5 expression via a direct interaction with its promoter region. This activation provides a regulatory link between cellular energy status and DUSP5 expression. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $51.00 $77.00 $102.00 $153.00 $2856.00 | 7 | |
Fisetin, a flavonoid, indirectly activates DUSP5 by inhibiting the PI3K/Akt pathway. By suppressing Akt activity, Fisetin relieves its inhibitory effect on DUSP5 expression, resulting in enhanced DUSP5-mediated dephosphorylation of MAPKs. This indirect activation highlights the interplay between the PI3K/Akt and MAPK pathways in regulating DUSP5, offering a potential avenue for modulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, another flavonoid, acts as an indirect activator by inhibiting the JNK pathway. Through its ability to suppress JNK activity, Quercetin relieves the negative feedback on DUSP5, allowing for increased dephosphorylation of MAPKs. This modulation exemplifies the intricate crosstalk between JNK signaling and DUSP5 activity, providing a potential avenue for pharmacological intervention. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, an isothiocyanate found in cruciferous vegetables, activates DUSP5 through the Nrf2/ARE pathway. By promoting Nrf2 activation, Sulforaphane enhances the transcription of DUSP5, leading to increased expression and subsequent dephosphorylation of MAPKs. This connection underscores the role of cellular stress response pathways in regulating DUSP5 activity. | ||||||
Gingerol | 23513-14-6 | sc-201519 sc-201519A | 5 mg 20 mg | $107.00 $379.00 | 5 | |
Gingerol, a bioactive compound in ginger, activates DUSP5 via inhibition of the NF-κB pathway. By suppressing NF-κB activity, Gingerol alleviates its inhibitory effect on DUSP5 expression, facilitating enhanced dephosphorylation of MAPKs. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic Acid, a triterpenoid present in various plants, activates DUSP5 through modulation of the mTOR pathway. By inhibiting mTOR signaling, Ursolic Acid enhances DUSP5 expression, leading to increased dephosphorylation of MAPKs. This connection emphasizes the regulatory crosstalk between mTOR and DUSP5, providing a potential avenue for targeted intervention in cellular growth and proliferation processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG), a catechin in green tea, indirectly activates DUSP5 by inhibiting the ERK pathway. Through its ability to suppress ERK activity, EGCG relieves the negative feedback on DUSP5, allowing for increased dephosphorylation of MAPKs. This modulation exemplifies the intricate crosstalk between EGFR signaling and DUSP5 activity, providing a potential avenue for pharmacological intervention. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol, a natural stilbene, activates DUSP5 through inhibition of the p38 pathway. By suppressing p38 activity, Piceatannol alleviates its inhibitory effect on DUSP5 expression, facilitating enhanced dephosphorylation of MAPKs. This indirect activation highlights the interplay between stress-responsive signaling and DUSP5 activity, offering a potential avenue for pharmacological modulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone found in soy, indirectly activates DUSP5 by inhibiting the c-Jun pathway. Through its ability to suppress c-Jun activity, Genistein relieves the negative feedback on DUSP5, allowing for increased dephosphorylation of MAPKs. This modulation exemplifies the intricate crosstalk between estrogen signaling and DUSP5 activity, providing a potential avenue for pharmacological intervention. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid, a natural pentacyclic triterpene, activates DUSP5 through modulation of the Wnt/β-catenin pathway. By inhibiting Wnt signaling, Betulinic Acid enhances DUSP5 expression, leading to increased dephosphorylation of MAPKs. This connection underscores the regulatory crosstalk between Wnt signaling and DUSP5, providing a potential avenue for targeted intervention in cellular differentiation processes. | ||||||