DR1 Activators
DR1, known as a transcriptional co-repressor, is intricately involved in the nuanced orchestration of gene expression. Understanding the chemicals that can influence its function, even indirectly, offers profound insights into cellular transcriptional dynamics. Histone deacetylase, such as Trichostatin A (TSA), Sodium Butyrate, Valproic Acid, and SAHA, shed light on the intertwining of epigenetics and transcriptional regulation. Their primary function is to alter chromatin structure, modulating gene expression landscapes. In doing so, they can influence the recruitment dynamics of co-repressors like DR1, altering their regulatory impact on specific genes. For instance, TSA's effect on histone acetylation can affect DR1's binding to gene promoters, providing an indirect means of modulation.
Retinoic Acid and Dexamethasone offer a different dimension. These compounds, known to influence specific gene expression patterns, operate by modulating nuclear receptors' transcriptional activities. The cellular response to such molecules invariably requires a symphony of co-activators and co-repressors, with DR1 playing a pivotal role. Compounds like AICAR and Curcumin bring forth the importance of key signaling pathways, such as AMPK and NF-kB, respectively, in influencing the dynamics of transcriptional regulation. They showcase the vast interconnected web of signaling cascades and their to influence co-repressors like DR1. PMA's modulation of the PKC pathway underscores the importance of protein kinases in transcriptional processes, emphasizing that altering such pathways can indirectly influence DR1's functional roles.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid influences gene expression and transcriptional processes via retinoic acid receptors. This might have an indirect influence on DR1, as it regulates various genes and can modulate transcriptional co-repressors like DR1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase inhibitor, altering chromatin structure and gene expression. By influencing histone acetylation, TSA can potentially affect the recruitment of co-repressors like DR1 to specific gene promoters. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid affecting various transcriptional processes. Its influence on glucocorticoid-responsive genes can indirectly affect the recruitment and function of co-repressors like DR1. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound is a DNA methyltransferase inhibitor, impacting DNA methylation and gene expression. Changes in DNA methylation can influence the binding and function of transcriptional co-repressors like DR1. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, a histone deacetylase inhibitor, impacts gene expression via histone modification. Influencing epigenetic processes can indirectly modulate the binding and activity of transcriptional co-repressors like DR1. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid inhibits histone deacetylase, influencing gene transcription processes. The resulting changes in chromatin structure can indirectly affect the recruitment and function of co-repressors like DR1. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione can influence the MAPK pathway. As DR1 interacts with other transcriptional regulators, alterations in pathways like MAPK can indirectly impact the functional roles and recruitment of DR1 in transcriptional regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is another histone deacetylase inhibitor affecting chromatin structure and transcription. By modulating histone acetylation, it can indirectly influence the recruitment and function of transcriptional co-repressors like DR1. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR affects the AMPK pathway. Given that AMPK can influence various transcriptional processes, AICAR, through AMPK modulation, can potentially have indirect effects on transcriptional co-repressors like DR1 and their binding partners. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate sirtuins, proteins influencing cellular aging and transcription. The modulation of sirtuins and associated pathways can have an indirect effect on transcriptional co-repressors like DR1 and their regulatory roles. | ||||||