DPEP2 Activators

DPEP2 Activators represent a group of chemical compounds that directly or indirectly enhance the functional activity of the DPEP2 protein. This is primarily achieved through a variety of mechanisms, including the regulation of intracellular calcium levels, modulation of energy status, and influence on various signaling pathways. The polyamines spermine and spermidine, along with NMDA, a specific agonist for NMDA receptors, can regulate intracellular calcium levels, a key factor known to modulate the activity of DPEP2. ATP, a purine nucleotide involved in energy transfer and signal transduction, can indirectly influence the activity of DPEP2 by affecting the energy status of the cell and modulating various signaling pathways.

L-Glutamate, an essential compound in cellular metabolism, and the amino acids glycine, D-serine, L-aspartate, and L-arginine, can also indirectly enhance the activity of DPEP2 by influencing various signaling pathways. D-Serine, in particular, acts as a co-agonist at the NMDA receptor, thereby influencing NMDA receptor signaling and subsequent calcium levels. Additionally, certain essential ions, such as Zn2+, Cu2+, and Ni2+, can interact with and modify the structural conformation of DPEP2, thereby indirectly enhancing its activity.