Date published: 2025-10-16

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DP-3 Inhibitors

DP-3 inhibitors are a class of chemical compounds that are designed to selectively interact with and inhibit the activity of a target enzyme known as Dipeptidyl Peptidase 3 (DP-3). DP-3 is an intracellular peptidase that is known to cleave a variety of dipeptides from the N-terminus of polypeptides, playing a role in the regulation of several physiological processes. The specificity of DP-3 inhibitors lies in their ability to bind to the active site or other strategic locations of the enzyme, thereby obstructing its natural peptidase activity. These inhibitors are typically characterized by their structural elements that are complementary to the active site of DP-3, enabling them to effectively reduce the enzyme's activity. The design of these compounds is informed by detailed knowledge of the enzyme's structure, substrate specificity, and catalytic mechanism. Inhibitors may be developed through a variety of methods, including rational design based on the enzyme's 3D structure, virtual screening, and optimization of lead compounds through medicinal chemistry approaches. The research and development of DP-3 inhibitors involve a multidisciplinary approach, drawing on fields such as biochemistry, molecular biology, and organic chemistry. Scientists seek to understand the precise interactions between DP-3 and its substrates, which involves studying the enzyme's substrate recognition patterns, catalytic kinetics, and the structural dynamics that govern its function. This deep dive into the enzyme's properties aids in the identification of potential inhibitory molecules that can form stable, non-covalent interactions with DP-3, effectively reducing its peptidase activity. Advanced techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and computational modeling play significant roles in visualizing the interaction between DP-3 and its inhibitors at an atomic level.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

PI3K inhibitor; can block the PI3K/AKT pathway, possibly affecting proteins regulated by this pathway.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$47.00
$145.00
51
(1)

Src-family kinase inhibitor; can inhibit tyrosine kinase activity, affecting proteins involved in signal transduction.

Alsterpaullone

237430-03-4sc-202453
sc-202453A
1 mg
5 mg
$67.00
$306.00
2
(1)

Cyclin-dependent kinase inhibitor; can block cell cycle progression, affecting proteins involved in cell division.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

p38 MAPK inhibitor; can inhibit proteins in the MAPK signaling pathway, which are involved in inflammatory responses.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

PI3K inhibitor; can disrupt the PI3K/AKT pathway, affecting downstream protein activity and cellular processes.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

mTOR inhibitor; can inhibit mTOR signaling, affecting protein synthesis and cellular growth.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

SERCA pump inhibitor; can disrupt calcium homeostasis, affecting proteins dependent on calcium signaling.

Temozolomide

85622-93-1sc-203292
sc-203292A
25 mg
100 mg
$89.00
$250.00
32
(1)

DNA alkylating agent; can cause DNA damage, affecting proteins involved in DNA repair and cell cycle control.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

Proteasome inhibitor; can prevent protein degradation, potentially affecting proteins that require proteasomal degradation for regulation.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$65.00
$210.00
26
(2)

Glycolysis inhibitor; can disrupt energy metabolism, affecting proteins that rely on glycolytic ATP production.