DOHH Activators
DOHH Activators include a variety of chemical compounds that indirectly influence the protein's function through modulation of iron homeostasis and other metabolic pathways. Deferiprone, 2,2'-Dipyridyl, Deferasirox, EDTA, and Ciclopirox, all function as iron chelators. These compounds can enhance DOHH's enzymatic activity in eIF5A hypusination, a process critical for eukaryotic cell proliferation and viability, by influencing iron availability. Iron is a cofactor essential for DOHH's iron-dependent dioxygenase function; hence, modulating iron levels directly impacts DOHH's activity. Similarly, L-Ascorbic acid, free acid, by acting as a reducing agent, can maintain iron in a reduced state, necessary for DOHH's function.
Other compounds like Dipyridamole and Hydroxyurea influence DOHH activity through more indirect pathways. Dipyridamole, by affecting adenosine uptake, impacts metabolic processes that intersect with DOHH's role. Hydroxyurea, by influencing ribonucleotide reductase, affects the nucleotide pool, indirectly affecting DOHH's functional context. Additionally, Chloroquine, through its impact on endosomal pH and iron homeostasis, can modulate DOHH activity. Theophylline, as a phosphodiesterase inhibitor, potentially impacts DOHH via cAMP-mediated pathways. Disulfiram and Quercetin, through their effects on metal homeostasis, especially iron, can enhance DOHH's activity. These compounds, in various ways, modulate the iron availability and metabolic pathways, thereby indirectly augmenting the functional activity of DOHH, particularly in its role in eIF5A hypusination, essential for cell proliferation and survival.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Deferiprone | 30652-11-0 | sc-211220 sc-211220A | 1 g 5 g | $124.00 $134.00 | 5 | |
Chelates iron, which could indirectly enhance DOHH's enzymatic activity involved in eIF5A hypusination, as DOHH requires iron as a cofactor. | ||||||
Deferasirox | 201530-41-8 | sc-207509 | 2.5 mg | $180.00 | 9 | |
Iron chelator that could indirectly enhance DOHH function by modulating iron levels, essential for DOHH's catalytic activity in eIF5A hypusination. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $31.00 $102.00 | 1 | |
Influences cellular uptake of adenosine, which could indirectly affect DOHH activity through adenosine-mediated pathways, as adenosine has been implicated in regulating various metabolic processes that might intersect with DOHH's function. | ||||||
Ciclopirox | 29342-05-0 | sc-217893 | 25 mg | $207.00 | 2 | |
An iron chelator, potentially enhancing DOHH activity by modulating iron availability, crucial for DOHH's enzymatic function in hypusinating eIF5A. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Acts as a reducing agent and could enhance DOHH activity by maintaining iron in a reduced state, which is necessary for DOHH's iron-dependent dioxygenase function. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Influences ribonucleotide reductase, potentially impacting DOHH activity by modulating the pool of nucleotides and thus affecting cellular processes in which DOHH is involved. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Alters endosomal pH and iron homeostasis, potentially enhancing DOHH activity by affecting cellular iron distribution, which is crucial for DOHH's function. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
A phosphodiesterase inhibitor, which could indirectly affect DOHH function through cAMP-mediated pathways that may intersect with DOHH's role in eIF5A hypusination. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Alters metal homeostasis, including iron, potentially enhancing DOHH activity by influencing iron availability, essential for its catalytic function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Modulates various signaling pathways, including those involving metal ions, potentially enhancing DOHH activity by affecting iron homeostasis, crucial for its iron-dependent dioxygenase activity. | ||||||