Ciclopirox (CAS 29342-05-0)
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Ciclopirox, a synthetic antifungal agent, has been extensively researched for its broad-spectrum antimicrobial properties and potential applications in various scientific fields. Its mechanism of action primarily involves interfering with the function of fungal enzymes, particularly those involved in ergosterol biosynthesis, a crucial component of fungal cell membranes. Ciclopirox inhibits the activity of fungal cytochrome P450-dependent enzymes, specifically CYP51, leading to disruption of ergosterol synthesis and accumulation of toxic sterol intermediates within fungal cells. Consequently, this disrupts membrane integrity, impairs membrane fluidity, and ultimately leads to fungal cell death. In research, ciclopirox has been investigated for its efficacy against a wide range of fungal pathogens, including dermatophytes, yeasts, and molds. Additionally, its potential as an antiparasitic agent against protozoan parasites has been explored. Furthermore, studies have focused on elucidating the molecular mechanisms underlying ciclopirox resistance in fungal species, aiming to develop strategies to overcome resistance and improve outcomes. Overall, ciclopirox remains a valuable tool in microbial research for studying fungal biology, pathogenesis, and antimicrobial resistance mechanisms.
Ciclopirox (CAS 29342-05-0) References
- Repositioning the Old Fungicide Ciclopirox for New Medical Uses. | Shen, T. and Huang, S. 2016. Curr Pharm Des. 22: 4443-50. PMID: 27238364
- Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly. | Kang, JA., et al. 2019. Nat Commun. 10: 2184. PMID: 31097716
- Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer. | Qi, J., et al. 2020. Cell Death Dis. 11: 582. PMID: 32719342
- Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling. | Su, Z., et al. 2021. Cell Death Dis. 12: 251. PMID: 33674562
- Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells. | Lu, J., et al. 2022. Cell Commun Signal. 20: 37. PMID: 35331268
- Ciclopirox inhibits NLRP3 inflammasome activation via protecting mitochondria and ameliorates imiquimod-induced psoriatic inflammation in mice. | Liang, S., et al. 2022. Eur J Pharmacol. 930: 175156. PMID: 35868446
- An Overview of the Diagnosis and Management of Seborrheic Dermatitis. | Dall'Oglio, F., et al. 2022. Clin Cosmet Investig Dermatol. 15: 1537-1548. PMID: 35967915
- Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells. | Chen, L., et al. 2022. Cell Death Dis. 13: 1007. PMID: 36443287
- Ciclopirox Inhibition of eIF5A Hypusination Attenuates Fibroblast Activation and Cardiac Fibrosis. | Subbaiah, KCV., et al. 2023. J Cardiovasc Dev Dis. 10: PMID: 36826549
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ciclopirox, 25 mg | sc-217893 | 25 mg | $207.00 |