Date published: 2026-1-30

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Dnmt Inhibitors

Santa Cruz Biotechnology now offers a broad range of Dnmt Inhibitors for use in various applications. DNA methyltransferases (Dnmt) are enzymes that play a crucial role in the epigenetic regulation of gene expression by adding methyl groups to the DNA molecule, typically at cytosine residues within CpG dinucleotides. This methylation process is essential for normal development, genomic stability, and the regulation of gene activity. Dnmt Inhibitors are important tools in scientific research, enabling researchers to study the effects of inhibiting DNA methylation on gene expression, chromatin structure, and cellular processes. By blocking Dnmt activity, scientists can explore how changes in DNA methylation patterns impact cellular differentiation, genomic imprinting, and the regulation of various biological pathways. These inhibitors are widely used in studies focused on understanding the role of DNA methylation in development, aging, and the response to environmental factors. Additionally, Dnmt Inhibitors are valuable for investigating the mechanisms by which epigenetic modifications contribute to complex traits and diseases, particularly in research aimed at uncovering how alterations in DNA methylation are associated with gene silencing, chromatin remodeling, and changes in cell fate. The availability of these inhibitors has significantly advanced research in fields such as epigenetics, molecular biology, and developmental biology, providing essential tools for dissecting the intricate networks of gene regulation controlled by DNA methylation. View detailed information on our available Dnmt Inhibitors by clicking on the product name.

Items 11 to 12 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Fluoro-2′-deoxycytidine

10356-76-0sc-252267
5 mg
$70.00
1
(0)

5-Fluoro-2'-deoxycytidine acts as a Dnmt inhibitor by incorporating into DNA, where it mimics natural nucleotides. This substitution disrupts normal methylation processes, influencing gene regulation. The fluorine atom enhances the compound's stability and alters hydrogen bonding patterns, affecting enzyme affinity. Its unique interactions with Dnmt enzymes can lead to altered reaction kinetics, ultimately impacting epigenetic modifications and cellular processes.

SGI-1027

1020149-73-8sc-473875
10 mg
$213.00
(0)

SGI-1027 functions as a Dnmt inhibitor through its ability to form stable complexes with DNA, leading to altered methylation patterns. Its unique structure allows for specific interactions with the active site of Dnmt enzymes, modulating their activity. The compound's distinct electronic properties facilitate enhanced binding affinity, while its steric configuration influences the kinetics of methylation reactions. This results in significant alterations in epigenetic landscapes and gene expression dynamics.