5-Fluoro-2′-deoxycytidine (CAS 10356-76-0)
別名:
2′-deoxy-5-fluoro-Cytidine; FCDR
アプリケーション：
5-Fluoro-2′-deoxycytidine is a mechanism-based DNMT inhibitor
CAS 番号:
10356-76-0
Purity:
≥98%
Molecular Weight:
245.21
Molecular Formula:
C9H12FN3O4
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
Mechanism-based DNMT inhibitor, shown to form covalent links with the cysteine residue in the DNMT active site.
参考文献
1. Zheng, Y. G., et al., Chemical Regulation of Epigenetic Modifications: Opportunities for New Cancer Therapy. Med. Res. Rev. 28, 645-687, (2008) Warncke S, et al., Phosphorothioation of oligonucleotides strongly influences the inhibition of bacterial (M.HhaI) and human (Dnmt1) DNA methyltransferases. ChemBioChem. 10, 728-734, (2009) 2. Beumer, J.H., et al., Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice. Clin. Cancer Res. 12, 7483-7491, (2006)
Appearance
:
Powder
Physical State
:
Solid
Solubility
:
Soluble in DMSO: >20 mg/mL
保存方法
:
Store at room temperature
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID
:
MDL Number
:
MFCD00077348
SMILES
:
Download SDS (MSDS)
分析表
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