Date published: 2026-2-3

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DNA pol ε Inhibitors

Santa Cruz Biotechnology now offers a broad range of DNA pol epsilon Inhibitors for use in various applications. DNA polymerase epsilon (pol epsilon) is a key enzyme involved in the replication of the leading strand of DNA during cell division and also plays a crucial role in DNA repair and maintaining genomic stability. DNA pol epsilon Inhibitors are vital tools in scientific research, enabling the detailed study of this enzyme's function in DNA synthesis and its interaction with other components of the replication machinery. Researchers use these inhibitors to investigate the effects of disrupting pol epsilon activity, providing insights into how the enzyme contributes to high-fidelity DNA replication and the prevention of mutations. These inhibitors are commonly employed in biochemical assays to study the kinetics of DNA synthesis, the response of cells to replication stress, and the mechanisms by which pol epsilon collaborates with other polymerases and proteins during replication. Additionally, DNA pol epsilon Inhibitors are valuable in exploring the cellular consequences of impaired DNA replication, such as genomic instability and the activation of DNA damage response pathways. The availability of these inhibitors has significantly advanced research in molecular biology, genetics, and cell biology, offering critical tools for dissecting the complex processes that ensure accurate DNA replication and the maintenance of genomic integrity. View detailed information on our available DNA pol epsilon Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

1-β-D-Arabinofuranosylcytosine

147-94-4sc-201628
sc-201628A
sc-201628B
sc-201628C
sc-201628D
1 g
5 g
25 g
100 g
250 g
$150.00
$263.00
$518.00
$731.00
$1461.00
1
(1)

1-β-D-Arabinofuranosylcytosine serves as a potent inhibitor of DNA polymerase epsilon, characterized by its ability to mimic natural nucleotides. This compound engages in specific interactions with the enzyme, leading to conformational changes that hinder its catalytic activity. The unique stereochemistry of 1-β-D-Arabinofuranosylcytosine enhances its binding affinity, resulting in altered reaction kinetics and a significant impact on the replication fork dynamics during DNA synthesis.