DNA Ligase IV Activators
DNA Ligase IV Activators belong to a chemical class of compounds that are involved in the modulation of DNA Ligase IV, a critical enzyme in the process of DNA repair. DNA Ligase IV is primarily known for its role in the non-homologous end joining (NHEJ) pathway, one of the main mechanisms for repairing double-strand breaks (DSBs) in DNA. Double-strand breaks are highly detrimental to the integrity of the genome and can lead to mutations, genomic instability, and cell death. DNA Ligase IV catalyzes the ligation or joining of broken DNA ends by forming a phosphodiester bond between them, thus sealing the break and restoring the DNA's continuity. This repair process is essential for maintaining genomic stability and preventing the accumulation of genetic mutations.
The mechanism of action of DNA Ligase IV Activators typically involves binding to specific regions of the DNA Ligase IV protein, inducing conformational changes that can enhance or inhibit its enzymatic activity. By modulating DNA Ligase IV activity, these activators influence the efficiency and fidelity of DNA repair through the NHEJ pathway. Research into DNA Ligase IV Activators provides valuable insights into the complex regulatory mechanisms governing DNA repair processes and genomic stability. Understanding how these activators interact with DNA Ligase IV contributes to our knowledge of the intricate processes involved in maintaining the integrity of the genetic material.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a compound that induces DNA double-strand breaks. As part of the non-homologous end joining pathway to repair such breaks, etoposide has the potential to upregulate DNA Ligase IV through activation of the DNA damage response network. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
By introducing crosslinks in DNA that cause breaks upon replication, cisplatin may signal for increased DNA Ligase IV to help repair platinum-DNA adducts and ensure genome stability. | ||||||
FCM Fixation buffer (10X) | sc-3622 | 10 ml @ 10X | $62.00 | 16 | ||
FCM Fixation buffer (10X) is widely used in various industrial and household products. It is genotoxic, causing DNA-protein and DNA interstrand crosslinks. Upregulation of DNA Ligase IV may be part of cellular response pathways attempting to resolve formaldehyde-DNA adducts and prevent mutations. | ||||||
Chlorambucil | 305-03-3 | sc-204682 sc-204682A | 250 mg 1 g | $52.00 $122.00 | 3 | |
Chlorambucil is an alkylating agent found in mustard gas. By introducing monoadducts and interstrand crosslinks into DNA, chlorambucil is genotoxic and could lead to elevated DNA Ligase IV levels through activation of DNA damage signaling. | ||||||
Benzo[a]pyrene | 50-32-8 | sc-257130 | 1 g | $612.00 | 4 | |
Benzo[a]pyrene found in cigarette smoke and charbroiled foods, among other sources, can produce bulky DNA adducts and crosslinks. Increased DNA Ligase IV expression may assist in DNA repair of benzo[a]pyrene lesions as an adaptive response to carcinogenic stress. | ||||||