DJ-1 Activators
Common DJ-1 Activators include, but are not limited to Resveratrol CAS 501-36-0, D,L-Sulforaphane CAS 4478-93-7, Rapamycin CAS 53123-88-9, 3-Hydroxytyramine, Hydrochloride CAS 62-31-7 and (-)-Epigallocatechin Gallate CAS 989-51-5.
DJ-1 activators are compounds that stimulate the activity or expression of DJ-1, a protein that plays diverse roles in cellular processes. DJ-1, also known as PARK7, is an evolutionarily conserved protein found in various organisms, from bacteria to humans. Its multifunctionality encompasses roles in antioxidative stress response, chaperone activity, transcriptional regulation, and mitochondrial function, among others.
At a molecular level, DJ-1 possesses a unique cysteine residue, Cys106, which is susceptible to oxidative modifications. This particular cysteine can undergo oxidation in response to cellular oxidative stress, converting DJ-1 into an acidic isoform that exhibits potent antioxidant properties. By neutralizing reactive oxygen species (ROS) and promoting cellular survival under oxidative stress conditions, DJ-1 acts as a crucial guardian of cell health. Additionally, DJ-1 is involved in regulating various signaling pathways, influencing cell growth and survival. DJ-1 activators, by enhancing the protein's activity or expression, can amplify its protective effects against oxidative stress and modulate its regulatory roles in various cellular pathways. Given the central role of DJ-1 in cellular defense against oxidative damage and its implications in maintaining cellular homeostasis, understanding the mechanisms and effects of DJ-1 activation offers deep insights into cellular stress response and resilience. Exploring the realm of DJ-1 activators underscores the importance of this protein in safeguarding cellular integrity and function, highlighting the broader context of cellular mechanisms that combat environmental and intrinsic challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural polyphenol found in grapes and red wine. It has been shown to upregulate DJ-1 expression, potentially through its antioxidant properties and ability to activate the SIRT1 pathway. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, can elevate DJ-1 levels. Its neuroprotective effects are thought to be linked to its ability to activate the Nrf2/ARE pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, has been suggested to increase DJ-1 expression. DJ-1 upregulation by rapamycin might be linked to autophagy induction. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Chronic exposure to dopamine can elevate DJ-1 levels. DJ-1 is believed to protect dopaminergic neurons from dopamine-induced oxidative stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major polyphenol in green tea, has been shown to increase DJ-1 expression. Its neuroprotective effects might be associated with its antioxidant properties. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC, a precursor to the antioxidant glutathione, can elevate DJ-1 levels, potentially due to its antioxidant and neuroprotective effects. | ||||||
Uric acid | 69-93-2 | sc-213135 sc-213135A sc-213135B | 25 g 100 g 500 g | $55.00 $137.00 $625.00 | 4 | |
Elevated uric acid levels have been associated with increased DJ-1 expression. The mechanism is not entirely clear, but it might be related to uric acid's antioxidant properties. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $193.00 $213.00 $317.00 | 1 | |
Riluzole, used in ALS treatment, can influence DJ-1 levels. The mechanism might be related to its neuroprotective effects. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $84.00 $166.00 $302.00 $2091.00 $5212.00 $16657.00 | 51 | |
Rottlerin has been suggested to upregulate DJ-1. The exact mechanism is unclear but might be linked to its effects on various signaling pathways. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Phenylbutyrate can elevate DJ-1 levels. It has histone deacetylase inhibitory activity and might influence gene expression. | ||||||