DHRS1 Activators
DHRS1 Activators encompass a diverse group of chemical compounds that influence the functional activity of the enzyme dehydrogenase/reductase (SDR family) member 1 (DHRS1) through various biochemical and cellular pathways. Retinol, a precursor of retinoic acid, enhances DHRS1's activity by driving the enzymatic demand for its oxidation process. This is due to DHRS1's role in the reversible conversion between retinol and retinaldehyde. NAD+ and NADH, as cofactors for the oxidation-reduction reactions catalyzed by DHRS1, directly support its enzymatic activity by facilitating the transfer of electrons in these reactions. An increase in cellular NAD+ can enhance DHRS1's oxidation of retinol, while NADH can stimulate the reverse reaction, overall promoting a dynamic equilibrium that increases the enzyme's turnover.
Fatty acids like palmitic and oleic acids are involved in modulating the lipid environments where membrane-bound enzymes like DHRS1 operate. By integrating into cell membranes, they can enhance DHRS1 activity by optimizing substrate accessibility and enzyme efficiency. Phosphatidylethanolamine, through its effects on membrane properties, can also support the enzyme's function by ensuring that DHRS1 maintains proper localization and interaction with its substrates. Zinc, although not a direct cofactor for DHRS1, can enhance its activity by stabilizing the enzyme structure and improving the overall catalytic environment. Carotenoids such as lutein and zeaxanthin provide additional substrates for DHRS1, thereby indirectly supporting its activity through substrate availability and participation in redox cycling. Alpha-lipoic acid and ubiquinone (Coenzyme Q10) can alter the cellular redox state, which is crucial for maintaining the enzyme's activity by ensuring a supply of NAD+ for DHRS1's catalysis. Lastly, squalene, by affecting membrane composition, can enhance the activity of DHRS1, as the enzyme's function is partially dependent on its interaction with the lipid bilayer, which dictates substrate availability and enzyme stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
Retinol, a form of Vitamin A, can be oxidized to retinoic acid by dehydrogenases such as DHRS1. Retinoic acid, in turn, influences gene expression via retinoic acid receptors, which can enhance the functional activity of DHRS1 by increasing the demand for its enzymatic activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ serves as a cofactor for DHRS1 during the reduction of retinoids. An increase in NAD+ levels can enhance the activity of DHRS1 by providing the necessary cofactor for its enzymatic action to reduce retinaldehydes to retinols. | ||||||
NADH disodium salt | 606-68-8 | sc-205762 sc-205762A | 500 mg 1 g | $91.00 $127.00 | 3 | |
NADH is the reduced form of NAD+ and is involved in the reverse reaction catalyzed by DHRS1. The presence of NADH can indirectly enhance the activity of DHRS1 by shifting the equilibrium towards the oxidation of retinols, thereby creating a substrate cycle that increases enzymatic turnover. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic acid can be incorporated into cellular membranes and may affect the activity of membrane-bound enzymes such as DHRS1 by changing the lipid environment. This can lead to an enhanced activity of DHRS1 through improved substrate interaction. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid is a monounsaturated fatty acid that can alter membrane fluidity. By integrating into cellular membranes, it can indirectly enhance the activity of DHRS1 by facilitating better substrate access and enzyme-substrate interactions. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc can act as a cofactor for some dehydrogenases and while it is not a direct cofactor for DHRS1, its presence can stabilize the structure of enzymes and enhance their activity by improving the catalytic environment. | ||||||
Xanthophyll | 127-40-2 | sc-220391 sc-220391A | 25 mg 100 mg | $250.00 $900.00 | 2 | |
Lutein, a carotenoid, is a substrate for oxidative enzymes and can indirectly enhance the activity of DHRS1 by participating in redox cycles that may regenerate cofactors required for DHRS1 activity. | ||||||
Zeaxanthin | 144-68-3 | sc-205544 sc-205544A | 500 µg 1 mg | $270.00 $463.00 | 5 | |
Zeaxanthin is another carotenoid that can engage in enzymatic reactions involving DHRS1. Its presence can enhance the functional activity of DHRS1 by providing alternative substrates for oxidation-reduction reactions. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid can influence mitochondrial function and redox status. By altering the redox state, it can indirectly enhance the enzymatic activity of DHRS1 by maintaining a favorable balance of NAD+/NADH. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Ubiquinone affects electron transport and mitochondrial function, which can influence the redox state of the cell. This can indirectly enhance DHRS1 activity by sustaining the levels of NAD+, necessary for its catalytic function. | ||||||