DHFRL1 Activators
DHFRL1 activators belong to a class of molecules that specifically influence the activity of the enzyme DHFRL1. The term activator in biochemistry often refers to a compound or substance that increases the rate of a particular enzymatic reaction by enhancing the activity of the enzyme in question. Such activators can achieve this by binding to specific sites on the enzyme, altering its conformation, or by facilitating interactions with its natural substrates. Enzyme activators typically work in contrast to inhibitors, which decrease enzyme activity.
The enzyme DHFRL1, or dihydrofolate reductase-like 1, plays a role in the complex biochemical pathways involving folate metabolism. Folate and its derivatives are essential for various cellular processes, such as DNA synthesis, repair, and methylation. By influencing DHFRL1's activity, DHFRL1 activators can directly affect these cellular processes, potentially influencing various aspects of cellular function, growth, and maintenance. Understanding and exploring the mechanisms by which these activators exert their influence is vital for comprehending their role in biochemistry and cellular physiology. It's worth noting that the modulation of DHFRL1's activity, through activators or otherwise, offers a deeper insight into the intricacies of cellular metabolism and the interplay of various enzymatic pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $80.00 $238.00 $825.00 | 5 | |
Pyrimethamine is an antimalarial compound that inhibits DHFR in Plasmodium species. Resistance to pyrimethamine can be conferred by increased expression of the enzyme. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
As a precursor in the tetrahydrofolate synthesis pathway, an abundance of folic acid might induce DHFR expression to metabolize excess dihydrofolate. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil impacts thymidylate synthase, a downstream enzyme in the tetrahydrofolate pathway. Cells may upregulate DHFR to compensate for perturbations in the pathway. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $49.00 $73.00 $270.00 $458.00 $1758.00 $114.00 | 16 | |
An abundance of thymidine may lead to increased demand for tetrahydrofolate cofactors. This can potentially induce DHFR expression to meet the demand. | ||||||
Sulfadoxine | 2447-57-6 | sc-212973 sc-212973A | 100 mg 1 g | $265.00 $1163.00 | ||
Sulfadoxine inhibits a step in the tetrahydrofolate synthesis pathway. The blockade might induce DHFR expression to enhance the pathway's efficiency. | ||||||
Benzoic acid | 65-85-0 | sc-203317 sc-203317A sc-203317B | 25 g 100 g 500 g | $20.00 $51.00 $61.00 | ||
Benzoic acid, in specific contexts, has been shown to interact with cellular metabolism and might influence DHFR expression indirectly. | ||||||
L-Phenylalanine | 63-91-2 | sc-394058 sc-394058A sc-394058B | 100 g 500 g 1 kg | $114.00 $466.00 $693.00 | 1 | |
Phenylalanine can impact various metabolic pathways. It's possible that its presence in certain conditions may indirectly induce DHFR expression. | ||||||
2-Propanol | 67-63-0 | sc-391000C sc-391000 sc-391000B sc-391000A | 1 ml 25 ml 100 ml 500 ml | $33.00 $53.00 $63.00 $89.00 | 1 | |
Isopropanol, at certain concentrations, can stress cells and induce various metabolic responses. One of these might be the upregulation of DHFR to handle disruptions in the tetrahydrofolate pathway. | ||||||