DHCR7 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AY 9944 | 366-93-8 | sc-202965 | 5 mg | $145.00 | 4 | |
AY 9944 is a selective inhibitor of DHCR7, an enzyme integral to cholesterol synthesis. Its unique structural features enable it to bind effectively to the enzyme's active site, thereby modulating the enzymatic activity. This interaction disrupts the normal metabolic pathway, resulting in altered sterol profiles. Furthermore, AY 9944 exhibits distinct physicochemical properties that influence its solubility and distribution in biological systems, impacting its overall bioavailability. | ||||||
BM 15766 sulfate | 86621-94-5 | sc-210953 sc-210953A | 1 mg 5 mg | $225.00 $849.00 | 1 | |
BM 15766 sulfate acts as a potent inhibitor of DHCR7, characterized by its ability to form stable complexes with the enzyme. This compound's unique molecular architecture facilitates specific interactions with key amino acid residues, leading to a significant reduction in enzymatic activity. The compound's kinetic profile reveals a rapid onset of inhibition, while its solubility characteristics suggest a favorable distribution in lipid-rich environments, enhancing its interaction with membrane-associated targets. | ||||||
Triparanol | 78-41-1 | sc-208472 sc-208472A | 5 mg 25 mg | $245.00 $811.00 | 1 | |
Previously used as a cholesterol-lowering agent, it inhibits DHCR7, but was withdrawn due to toxic side effects. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
Can inhibit DHCR7 and is used experimentally to induce a cellular model of Smith-Lemli-Opitz syndrome. | ||||||
Zaragozic Acid A | 142561-96-4 | sc-391058 sc-391058A | 1 mg 5 mg | $225.00 $615.00 | 7 | |
Also known as squalestatin, inhibits squalene synthase but may have downstream effects on DHCR7 activity. | ||||||
Terbinafine | 91161-71-6 | sc-338609 | 100 mg | $560.00 | 1 | |
An antifungal known to inhibit squalene epoxidase, could influence DHCR7 activity indirectly by substrate depletion. | ||||||
Fenpropimorph | 67564-91-4 | sc-396899C sc-396899D sc-396899A sc-396899E sc-396899 sc-396899B | 10 mg 25 mg 50 mg 100 mg 250 mg 1 g | $189.00 $250.00 $291.00 $393.00 $683.00 $2290.00 | 1 | |
A fungicide that inhibits sterol biosynthesis, potentially affecting DHCR7 by altering sterol precursor levels. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
While its primary target is HMG-CoA reductase, its downstream effects can reduce substrate availability for DHCR7. | ||||||
Pravastatin, Sodium Salt | 81131-70-6 | sc-203218 sc-203218A sc-203218B | 25 mg 100 mg 1 g | $69.00 $162.00 $787.00 | 2 | |
Another statin that, though targeting HMG-CoA reductase, may also impact DHCR7 function indirectly. | ||||||