AY 9944 CAS: 366-93-8
MF: C22H28Cl2N2•2HCl
MW: 464.30
A hedgehog inhibitor and DHCR7 inhibitor.

AY 9944 (CAS 366-93-8)

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AY 9944 is rated 5.0 out of 5 by 1.
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Nombres Alternativos: trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride
Solicitud: AY 9944 is a hedgehog inhibitor and DHCR7 inhibitor
Número de CAS: 366-93-8
Pureza: ≥99%
Peso Molecular: 464.30
Fórmula Molecular: C22H28Cl2N22HCl
Información suplementaria: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

AY 9944 is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. AY 9944 inhibits DHCR7 (Δ7-dehydrocholesterol reductase) (IC50 = 13 nM), thus reducing cholesterol biosynthesis, and also inhibiting cholesterol esterification. AY 9944 may also directly block the cellular response to hedgehog proteins. AY 9944 is an inhibitor of EBP.


References

1. Yoshida, Y., et al., 1985. Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs. Journal of biochemistry. 98(6): 1669-79. PMID: 2419314
2. Kraml, M., et al., 1964. Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. Biochemical and biophysical research communications. 15(5): 455-7. PMID: 4283982
3. Moebius, F F., et al., 1998. Molecular cloning and expression of the human delta7-sterol reductase. Proceedings of the National Academy of Sciences of the United States of America. 95(4): 1899-902. PMID: 9465114
4. Cooper, M K., et al., 1998. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science (New York, N.Y.). 280(5369): 1603-7. PMID: 9616123
5. Incardona, J P., et al., 1998. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development (Cambridge, England). 125(18): 3553-62. PMID: 9716521
6. Gofflot, F., et al., 2001. Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis. Developmental dynamics : an official publication of the American Association of Anatomists. 220(2): 99-111. PMID: 11169843

Estado de Materia :
Solid
Solubilidad :
Soluble in water (50 mM), and DMSO (14 mg/ml).
ALMACENAMIENTO :
Desiccate at 4° C
Punto de Fusión :
288-293.5° C (lit.)
Indice de Refracción :
n20D ~1.57 (Predicted)
IC50 :
DHCR7: IC50 = 13 nM
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
RTECS :
GU7025000
PubChem CID :
Número MDL :
MFCD01734586
SMILES :
C1CC(CCC1CNCC2=CC=CC=C2Cl)CNCC3=CC=CC=C3Cl.Cl.Cl

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AY 9944 (CAS 366-93-8)  Menciones del Producto

Ver como otros han utilizado AY 9944 (CAS 366-93-8). Haga click en la entrada de PubMed .

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PMID: # 30212566  Zhou, W.|Debnath, A.|Jennings, G.|Hahn, HJ.|Vanderloop, BH.|Chaudhuri, M.|Nes, WD.|Podust, LM.| et al. 2018. PLoS Pathog. 14: e1007245.

PMID: # 26923021  Kim, Y. et al. 2016. J. Alzheimers Dis. 51: 1057-68.

PMID: # 32994291  mSystems.

PMID: # 25985440  Virology. 218-28.

Citaciones 1 a 4 de un total de 4
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