desmoglein 2 Inhibitors
Desmoglein 2 Inhibitors belong to a specialized chemical class primarily recognized for their capacity to modulate a specific cellular component, desmoglein 2 (DSG2). Desmogleins are a group of cadherin-type cell adhesion molecules that play a pivotal role in maintaining tissue integrity, particularly in the epidermis and heart. DSG2, one of the isoforms of desmoglein, is predominantly found in cardiac tissue and skin, where it facilitates cell-to-cell adhesion by forming desmosomal junctions. These junctions are essential for the structural integrity of tissues, as they provide mechanical strength and ensure the proper functioning of the heart and skin under normal physiological conditions.
Inhibitors targeting desmoglein 2 typically interfere with the adhesive interactions between DSG2 molecules or disrupt the downstream signaling pathways associated with DSG2 function. By doing so, they have the ability to alter cell adhesion, ultimately affecting tissue cohesion and mechanical stability. Given the critical role of DSG2 in maintaining the structural integrity of the heart and skin, the development and study of desmoglein 2 inhibitors are of significant scientific interest.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can inhibit DNA methylation, potentially leading to the reactivation of silenced genes, which might affect the expression levels of DSG2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This compound is a histone deacetylase inhibitor, which can alter chromatin structure and subsequently impact gene expression, including that of DSG2. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, another histone deacetylase inhibitor, can change the acetylation status of histones, potentially affecting DSG2 transcription. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin has antioxidant properties and can influence various signaling pathways, potentially affecting the expression of proteins like DSG2. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, has been shown to influence gene expression, possibly impacting DSG2 levels. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As a phytoestrogen, genistein can modulate signaling pathways and gene expression, potentially affecting DSG2 levels. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A can bind to GC-rich DNA sequences, potentially inhibiting Sp1 transcription factor binding sites and affecting DSG2 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR signaling, which is involved in cell growth and protein synthesis, potentially leading to decreased DSG2 expression. | ||||||