desmoglein 2 Activators
Desmoglein 2 Activators belong to a specific chemical class known for their pivotal role in regulating cellular adhesion processes. Desmoglein 2, a member of the desmoglein family of cadherin proteins, is primarily found in the desmosomes of epithelial tissues. These cell-cell junctions play a fundamental role in maintaining tissue integrity by providing strong adhesion between neighboring cells. Desmoglein 2, in particular, is prominently expressed in tissues such as the heart, skin, and gastrointestinal tract, where the maintenance of tissue integrity is crucial for proper organ function. Desmoglein 2 activators are compounds or molecules that modulate the function of this cell adhesion protein, influencing its adhesive properties and impacting cellular interactions within these tissues.
The activation of desmoglein 2 is essential for strengthening cell-cell adhesion, ensuring the structural stability of tissues. Desmoglein 2 activators typically function by enhancing the binding affinity of desmoglein 2 with other desmosomal proteins, like desmocollins, forming strong adhesive bonds that resist mechanical stress and maintain tissue cohesion. These activators can also influence the signaling pathways involved in the regulation of desmoglein 2, ultimately contributing to the overall integrity and barrier function of epithelial tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, influences cell differentiation and proliferation. In certain cell types, it has been observed to modulate the expression of various cadherins, potentially including desmoglein 2. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
This compound is a DNA methyltransferase inhibitor, leading to demethylation of DNA and potentially resulting in the upregulation of certain genes, including those encoding for desmoglein 2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, this polyphenol has been shown to influence gene expression. It may have the potential to modulate the expression of proteins involved in cell adhesion, including desmoglein 2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a compound found in grapes and berries, is known to affect the expression of various genes. It has potential to influence the expression of cell adhesion molecules, including desmoglein 2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Derived from turmeric, curcumin has been observed to modulate gene expression. It could potentially influence the expression of desmoglein 2 and other proteins involved in cell adhesion. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
As a form of estrogen, 17-β-estradiol can bind to estrogen receptors and influence gene expression. It might play a role in modulating the expression of cell adhesion proteins, such as desmoglein 2. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As a reactive oxygen species, hydrogen peroxide can activate signaling pathways that may influence gene expression. It could potentially play a role in the upregulation of desmoglein 2 under certain conditions. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels. This can influence various cellular processes, potentially including the expression of proteins like desmoglein 2. | ||||||