Date published: 2025-10-16

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Derivatization Agents

Santa Cruz Biotechnology now offers a broad range of derivatization agents for use in various applications. Derivatization agents are critical compounds used to chemically modify analytes to enhance their detectability, stability, and chromatographic properties in analytical chemistry. These agents play a crucial role in techniques such as gas chromatography (GC), liquid chromatography (LC), and mass spectrometry (MS), where they help in converting non-volatile, thermally labile, or otherwise undetectable compounds into more amenable forms. Researchers utilize derivatization agents to improve the separation and detection of complex mixtures, enabling precise and accurate analysis of components at trace levels. In scientific research, these agents are employed to study a wide array of substances, including environmental pollutants, food additives and biological molecules. Derivatization can aid in the identification and quantification of amino acids, fatty acids, carbohydrates, and steroids, among others, by enhancing their chromatographic and spectrometric responses. By offering a comprehensive selection of high-quality derivatization agents, Santa Cruz Biotechnology supports advanced research and analytical methodologies across various fields, including biochemistry, environmental science, and forensic analysis. These agents empower scientists to achieve greater sensitivity and specificity in their analytical procedures, driving forward discoveries and innovations in their respective disciplines. View detailed information on our available derivatization agents by clicking on the product name.

Items 21 to 30 of 257 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

1-[2-(Trimethylsilyl)ethoxycarbonyloxy]benzotriazole

113306-55-1sc-287050
sc-287050A
1 g
5 g
$98.00
$420.00
(0)

1-[2-(Trimethylsilyl)ethoxycarbonyloxy]benzotriazole acts as a versatile derivatization agent, notable for its ability to form stable esters through acylation reactions. The presence of the trimethylsilyl group enhances solubility and reactivity, facilitating efficient interactions with nucleophiles. Its benzotriazole moiety contributes to strong π-π stacking interactions, improving the selectivity and sensitivity of analytical methods. This compound's unique structure allows for tailored modifications of functional groups, enhancing detection capabilities.

Trityl chloride

76-83-5sc-258321
sc-258321A
25 g
100 g
$21.00
$41.00
(0)

Trityl chloride serves as a potent derivatization agent, characterized by its ability to form robust trityl ethers through nucleophilic substitution. The bulky trityl group imparts steric hindrance, which can influence reaction kinetics and selectivity, making it particularly effective in protecting functional groups. Its electrophilic nature promotes rapid reactions with alcohols and amines, while the aromatic structure enhances π-π interactions, improving the stability of the resulting derivatives.

Trichloro(propyl)silane

141-57-1sc-255689
sc-255689A
25 g
100 g
$180.00
$568.00
(0)

Trichloro(propyl)silane acts as a versatile derivatization agent, notable for its ability to introduce silane functionalities onto various substrates. Its unique reactivity stems from the presence of multiple chlorine atoms, which facilitate nucleophilic attack and promote the formation of siloxane bonds. The propyl chain enhances hydrophobic interactions, influencing solubility and compatibility with organic matrices. This compound's reactivity can be finely tuned, allowing for selective modifications in complex chemical environments.

Trichloro(octyl)silane

5283-66-9sc-237274
100 g
$60.00
(0)

Trichloro(octyl)silane serves as an effective derivatization agent, characterized by its long octyl chain that enhances hydrophobicity and surface adhesion. The presence of three chlorine atoms enables robust nucleophilic substitution reactions, leading to the formation of stable siloxane linkages. Its unique structure allows for tailored interactions with various substrates, promoting selective functionalization. The compound's reactivity is influenced by steric factors, enabling precise control over reaction pathways in diverse chemical settings.

2-(Benzoyloxymethyl)benzoic acid

58249-83-5sc-223258
10 g
$357.00
(0)

2-(Benzoyloxymethyl)benzoic acid functions as a versatile derivatization agent, distinguished by its dual aromatic structure that facilitates π-π stacking interactions. This compound exhibits unique reactivity through its carboxylic acid group, enabling efficient esterification and acylation reactions. Its ability to form stable conjugates enhances selectivity in target modifications, while the benzoyloxy moiety contributes to increased solubility in organic solvents, optimizing reaction kinetics and product yields.

Chlorotrimethylsilane

75-77-4sc-294014
sc-294014A
250 ml
1 L
$41.00
$102.00
(0)

Chlorotrimethylsilane serves as a potent derivatization agent, characterized by its ability to introduce trimethylsilyl groups to various functional moieties. This compound exhibits rapid reactivity with alcohols and amines, facilitating the formation of stable silyl ethers and amines. Its unique silicon-oxygen bond enhances the stability of derivatives, while the steric bulk of the trimethylsilyl group improves selectivity in reactions, making it an effective tool for enhancing volatility and detectability in analytical applications.

p-Toluenesulfonyl chloride

98-59-9sc-255407
sc-255407A
5 g
100 g
$36.00
$158.00
(0)

p-Toluenesulfonyl chloride is a versatile derivatization agent known for its ability to form sulfonate esters with alcohols and amines, enhancing their reactivity and stability. Its electrophilic nature allows for selective acylation, promoting efficient nucleophilic attack. The presence of the toluene moiety contributes to increased lipophilicity, aiding in the extraction and purification of derivatives. This compound's unique reactivity profile makes it invaluable in modifying functional groups for improved analytical characterization.

Ferrocene

102-54-5sc-353607
sc-353607A
sc-353607B
25 g
500 g
1 kg
$51.00
$204.00
$406.00
1
(1)

Ferrocene serves as a unique derivatization agent due to its distinctive sandwich structure, which facilitates electron transfer and enhances reactivity. Its ability to form stable complexes with various nucleophiles allows for selective functionalization, promoting diverse reaction pathways. The presence of the ferrocene moiety imparts notable stability and solubility in organic solvents, making it an effective tool for modifying compounds and improving their analytical properties through enhanced detection and separation techniques.

Allyl bromide

106-95-6sc-280596
250 g
$46.00
(0)

Allyl bromide acts as a versatile derivatization agent, characterized by its ability to undergo nucleophilic substitution reactions. The presence of the allyl group allows for regioselective reactions, enabling the formation of diverse derivatives. Its reactivity is enhanced by the electrophilic nature of the bromine atom, facilitating rapid reaction kinetics. Additionally, the compound's moderate polarity aids in solubility, promoting effective interactions with various substrates during derivatization processes.

2-Chloroethyl vinyl ether

110-75-8sc-238003
25 g
$110.00
(0)

2-Chloroethyl vinyl ether serves as a potent derivatization agent, notable for its ability to engage in electrophilic addition reactions. The vinyl ether moiety enhances its reactivity, allowing for selective functionalization of nucleophiles. Its unique structure promotes the formation of stable adducts through ring-opening mechanisms, while the chlorine atom contributes to its electrophilic character. This compound's moderate volatility and reactivity facilitate efficient derivatization pathways, making it a valuable tool in synthetic chemistry.