Chlorotrimethylsilane (CAS 75-77-4)
Available in US only.
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Chlorotrimethylsilane, sometimes referred to as trimethylchlorosilane, is an organosilicon compound. It presents as a colorless, volatile liquid with a distinct smell and is highly combustible. This compound is employed in organic synthesis, serving as a reagent for creating organosilicon compounds and as a provider of silicon for the production of various products. It also finds use in the creation of specialty chemicals. Chlorotrimethylsilane′s versatility shows in organic synthesis, where it partakes in a multitude of reactions. It′s especially useful in synthesizing organosilicon compounds like silanes, siloxanes, and silazanes. Chlorotrimethylsilane is a nucleophilic reagent, enabling it to react with a range of electrophiles. It interacts with alkenes and alkynes to generate organosilicon compounds and with carbon-carbon double bonds to yield silazanes. It also reacts with aldehydes and ketones to produce siloxanes, and with alcohols to create silanes.
Chlorotrimethylsilane (CAS 75-77-4) References
- Chlorotrimethylsilane. | Buschmann, J., et al. 2000. Acta Crystallogr C. 56 (Pt 1): 121-2. PMID: 10710694
- Chlorotrimethylsilane as a reagent for gas chromatographic analysis of fats and oils. | Eras, J., et al. 2001. J Chromatogr A. 918: 227-32. PMID: 11403452
- Dealkylation of phosphonate esters with chlorotrimethylsilane. | Gutierrez, AJ., et al. 2001. Nucleosides Nucleotides Nucleic Acids. 20: 1299-302. PMID: 11563008
- Vibrational spectroscopic studies in the hydrolysis and condensation of chlorotrimethylsilane. | Li, YS. and Le, K. 2004. Spectrochim Acta A Mol Biomol Spectrosc. 60: 927-31. PMID: 15036105
- Desulfation of sulfated galactans with chlorotrimethylsilane. Characterization of beta-carrageenan by 1H NMR spectroscopy. | Kolender, AA. and Matulewicz, MC. 2004. Carbohydr Res. 339: 1619-29. PMID: 15183736
- Chlorotrimethylsilane, a reagent for the direct quantitative analysis of fats and oils present in vegetable and meat samples. | Eras, J., et al. 2004. J Chromatogr A. 1047: 157-61. PMID: 15481471
- Vibrational spectrum of chlorotrimethylsilane. | Montejo, M., et al. 2005. Spectrochim Acta A Mol Biomol Spectrosc. 62: 293-301. PMID: 16257728
- Chlorotrimethylsilane-nitrate salts as oxidants: direct oxidative conversion of thiols and disulfides to sulfonyl chlorides. | Prakash, GK., et al. 2007. J Org Chem. 72: 5847-50. PMID: 17585828
- Chlorotrimethylsilane-promoted one-pot synthesis of steroidal[17,16-d]pyrimidines. | Wang, C., et al. 2010. Steroids. 75: 1033-8. PMID: 20600203
- Chlorotrimethylsilane activation of acylcyanamides for the synthesis of mono-N-acylguanidines. | Looper, RE., et al. 2011. J Org Chem. 76: 6967-71. PMID: 21732649
- The effect of chlorotrimethylsilane on bonding of nano hydroxyapatite with a chitosan-polyacrylamide matrix. | Bhat Kalambettu, A., et al. 2012. Carbohydr Res. 352: 143-50. PMID: 22364767
- Chlorotrimethylsilane promoted one-flask heterocyclic synthesis of 1,2,4-triazoles from nitrilimines: Modeling studies and bioactivity evaluation of LH-21 and Rimonabant analogues. | Tsai, SE., et al. 2020. Bioorg Chem. 104: 104299. PMID: 33002729
- Synthesis of (±)-Emtricitabine and (±)-Lamivudine by Chlorotrimethylsilane-Sodium Iodide-Promoted Vorbrüggen Glycosylation. | Mear, SJ., et al. 2022. J Org Chem. 87: 2887-2897. PMID: 35030006
- Cu-catalysed transamidation of unactivated aliphatic amides. | Kumar, V., et al. 2022. Org Biomol Chem. 20: 6931-6940. PMID: 35983826
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chlorotrimethylsilane, 250 ml | sc-294014 | 250 ml | $41.00 | |||
| US: Only available in the US | ||||||
Chlorotrimethylsilane, 1 L | sc-294014A | 1 L | $102.00 | |||
| US: Only available in the US | ||||||