Date published: 2026-4-5

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Derivatization Agents

Santa Cruz Biotechnology now offers a broad range of derivatization agents for use in various applications. Derivatization agents are critical compounds used to chemically modify analytes to enhance their detectability, stability, and chromatographic properties in analytical chemistry. These agents play a crucial role in techniques such as gas chromatography (GC), liquid chromatography (LC), and mass spectrometry (MS), where they help in converting non-volatile, thermally labile, or otherwise undetectable compounds into more amenable forms. Researchers utilize derivatization agents to improve the separation and detection of complex mixtures, enabling precise and accurate analysis of components at trace levels. In scientific research, these agents are employed to study a wide array of substances, including environmental pollutants, food additives and biological molecules. Derivatization can aid in the identification and quantification of amino acids, fatty acids, carbohydrates, and steroids, among others, by enhancing their chromatographic and spectrometric responses. By offering a comprehensive selection of high-quality derivatization agents, Santa Cruz Biotechnology supports advanced research and analytical methodologies across various fields, including biochemistry, environmental science, and forensic analysis. These agents empower scientists to achieve greater sensitivity and specificity in their analytical procedures, driving forward discoveries and innovations in their respective disciplines. View detailed information on our available derivatization agents by clicking on the product name.

Items 181 to 190 of 257 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Chloro(dodecyl)dimethylsilane

66604-31-7sc-234318
25 ml
$105.00
(0)

Chloro(dodecyl)dimethylsilane serves as a versatile derivatization agent, notable for its ability to modify surfaces through silanization. The long dodecyl chain imparts hydrophobic characteristics, promoting unique interactions with organic substrates. Its reactivity stems from the chlorosilane functionality, enabling rapid covalent bonding with hydroxyl groups. This compound enhances surface properties, improving adhesion and stability in various applications, while its dimethyl groups contribute to steric hindrance, influencing reaction kinetics.

Chloro(dimethyl)thexylsilane

67373-56-2sc-252577
sc-252577A
sc-252577B
sc-252577C
1 g
5 g
25 g
100 g
$34.00
$114.00
$220.00
$371.00
(0)

Chloro(dimethyl)thexylsilane is an effective derivatization agent characterized by its unique branched structure, which facilitates selective surface modification. The presence of chlorosilane allows for efficient nucleophilic attack, leading to stable covalent linkages with hydroxyl and amine groups. Its dimethyl groups enhance steric bulk, influencing reaction rates and selectivity. This compound's ability to create tailored surface chemistries makes it valuable for enhancing material properties and compatibility in diverse environments.

tert-Butyldimethylsilyl trifluoromethanesulfonate

69739-34-0sc-251141
sc-251141A
sc-251141B
sc-251141C
1 g
5 g
100 g
500 g
$28.00
$62.00
$118.00
$407.00
(0)

tert-Butyldimethylsilyl trifluoromethanesulfonate serves as a versatile derivatization agent, notable for its trifluoromethanesulfonate moiety, which enhances electrophilicity. This feature promotes rapid and selective reactions with nucleophiles, facilitating the formation of stable silyl ethers. The tert-butyl group imparts steric hindrance, influencing reaction kinetics and selectivity, while the dimethylsilyl component provides enhanced stability and solubility in various organic solvents, making it a powerful tool in synthetic chemistry.

Chlorocyclohexyldimethylsilane

71864-47-6sc-234326
5 g
$135.00
(0)

Chlorocyclohexyldimethylsilane serves as an effective derivatization agent, notable for its ability to enhance the stability of siloxane bonds through steric hindrance and electronic effects. Its unique cyclohexyl group provides a hydrophobic environment, promoting selective interactions with polar substrates. The dimethyl groups contribute to its reactivity by facilitating nucleophilic substitution, while its silane functionality allows for versatile coupling reactions, enhancing analytical sensitivity in various applications.

1-(Methoxymethyl)-1H-benzotriazole

71878-80-3sc-222616
sc-222616A
250 mg
1 g
$24.00
$75.00
(0)

1-(Methoxymethyl)-1H-benzotriazole acts as a versatile derivatization agent, characterized by its ability to form stable adducts through strong π-π stacking interactions with aromatic compounds. The methoxymethyl group enhances solubility in organic solvents, facilitating smoother reaction kinetics. Its unique structure allows for selective functionalization, improving detection limits in analytical methods. Additionally, it can stabilize reactive intermediates, promoting efficient transformation pathways.

Triethylsilyl trifluoromethanesulfonate

79271-56-0sc-253753
10 g
$94.00
(0)

Triethylsilyl trifluoromethanesulfonate serves as a powerful derivatization agent, notable for its ability to introduce silyl groups that enhance the volatility and stability of target molecules. Its trifluoromethanesulfonate moiety facilitates rapid electrophilic reactions, promoting efficient acylation processes. The compound's unique reactivity profile allows for selective modifications, improving the resolution and sensitivity in chromatographic analyses. Its strong Lewis acid character also aids in activating substrates for subsequent transformations.

4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate

80149-80-0sc-252186
5 g
$365.00
(0)

4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate acts as a versatile derivatization agent, characterized by its ability to form stable carbonates that enhance the detection of analytes. The nitrophenyl group contributes to strong π-π stacking interactions, improving the compound's affinity for various substrates. Its unique reactivity allows for selective acylation, facilitating efficient coupling reactions. Additionally, the trimethylsilyl moiety increases hydrophobicity, aiding in the separation and analysis of complex mixtures.

Trimethyl(trifluoromethyl)silane

81290-20-2sc-358885
5 ml
$145.00
(0)

Trimethyl(trifluoromethyl)silane serves as a powerful derivatization agent, notable for its trifluoromethyl group that enhances electron-withdrawing properties, promoting selective reactions. This compound exhibits unique reactivity patterns, facilitating the formation of stable siloxane bonds. Its high volatility and low polarity improve analyte solubility and extraction efficiency, while the trimethylsilyl group provides steric hindrance, allowing for precise control in reaction kinetics and product formation.

9-Fluorenylmethyl 1-benzotriazolyl carbonate

82911-71-5sc-233732
5 g
$166.00
(0)

9-Fluorenylmethyl 1-benzotriazolyl carbonate is a versatile derivatization agent characterized by its ability to form stable carbonates through nucleophilic substitution. The presence of the benzotriazole moiety enhances its reactivity, promoting selective derivatization of alcohols and amines. Its unique structure allows for strong π-π stacking interactions, improving the stability of intermediates. Additionally, the compound's moderate polarity aids in solubility, facilitating efficient reaction pathways and product isolation.

9-Fluorenylmethyl carbamate

84418-43-9sc-233733
1 g
$114.00
(0)

9-Fluorenylmethyl carbamate serves as a powerful derivatization agent, notable for its ability to selectively modify amines and alcohols through carbamate formation. Its unique structure promotes intramolecular hydrogen bonding, enhancing reaction specificity and efficiency. The compound's steric bulk contributes to its selectivity, while its favorable solubility characteristics facilitate smooth reaction kinetics. This enables effective isolation of derivatives, making it a valuable tool in analytical chemistry.