Date published: 2025-10-17

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Derivatization Agents

Santa Cruz Biotechnology now offers a broad range of derivatization agents for use in various applications. Derivatization agents are critical compounds used to chemically modify analytes to enhance their detectability, stability, and chromatographic properties in analytical chemistry. These agents play a crucial role in techniques such as gas chromatography (GC), liquid chromatography (LC), and mass spectrometry (MS), where they help in converting non-volatile, thermally labile, or otherwise undetectable compounds into more amenable forms. Researchers utilize derivatization agents to improve the separation and detection of complex mixtures, enabling precise and accurate analysis of components at trace levels. In scientific research, these agents are employed to study a wide array of substances, including environmental pollutants, food additives and biological molecules. Derivatization can aid in the identification and quantification of amino acids, fatty acids, carbohydrates, and steroids, among others, by enhancing their chromatographic and spectrometric responses. By offering a comprehensive selection of high-quality derivatization agents, Santa Cruz Biotechnology supports advanced research and analytical methodologies across various fields, including biochemistry, environmental science, and forensic analysis. These agents empower scientists to achieve greater sensitivity and specificity in their analytical procedures, driving forward discoveries and innovations in their respective disciplines. View detailed information on our available derivatization agents by clicking on the product name.

Items 161 to 170 of 257 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Chloro(3-cyanopropyl)dimethylsilane

18156-15-5sc-227602
5 ml
$58.00
(0)

Chloro(3-cyanopropyl)dimethylsilane acts as a versatile derivatization agent, notable for its ability to introduce functional groups through nucleophilic attack. The presence of the cyanopropyl moiety enhances reactivity, promoting selective interactions with various nucleophiles. Its unique silane structure allows for effective cross-linking and stabilization of reaction intermediates, while its moderate polarity aids in solubility across a range of organic solvents, facilitating diverse synthetic pathways.

tert-Butylchlorodimethylsilane solution

18162-48-6sc-255639
50 g
$115.00
(0)

tert-Butylchlorodimethylsilane solution serves as an effective derivatization agent, characterized by its ability to form stable silyl ethers through electrophilic substitution. The tert-butyl group enhances steric hindrance, promoting selective reactivity and minimizing side reactions. Its unique silane framework allows for efficient protection of hydroxyl groups, while the chlorinated site facilitates nucleophilic displacement, enabling rapid and controlled reaction kinetics in various organic environments.

tert-Butyltrichlorosilane

18171-74-9sc-253648
sc-253648A
5 g
50 g
$348.00
$565.00
(0)

tert-Butyltrichlorosilane is a versatile derivatization agent known for its ability to introduce silyl groups onto various substrates. Its trichlorosilane structure allows for multiple chlorides to engage in nucleophilic reactions, enhancing the formation of silyl ethers and esters. The presence of the bulky tert-butyl group not only provides steric protection but also influences reaction pathways, leading to selective derivatization. This compound exhibits rapid reactivity, making it suitable for diverse organic transformations.

Di-tert-butyldichlorosilane

18395-90-9sc-239672
5 g
$173.00
(0)

Di-tert-butyldichlorosilane serves as an effective derivatization agent, characterized by its unique ability to form stable silyl derivatives through selective chlorination. The presence of two bulky tert-butyl groups imparts significant steric hindrance, which modulates reaction kinetics and enhances regioselectivity in nucleophilic substitutions. This compound's dual chlorosilane functionality facilitates the formation of robust siloxane bonds, promoting efficient coupling with various nucleophiles while minimizing side reactions.

Chloro(dimethyl)octadecylsilane

18643-08-8sc-252575
5 g
$23.00
(0)

Chloro(dimethyl)octadecylsilane serves as a potent derivatization agent, characterized by its ability to form robust siloxane bonds through nucleophilic substitution reactions. The presence of the chlorosilane group enhances reactivity, allowing for efficient surface modification and functionalization. Its long hydrophobic alkyl chain contributes to unique interactions with organic substrates, promoting enhanced adhesion and stability. This compound's reactivity is influenced by steric factors, enabling selective derivatization pathways.

Chlorotribenzylsilane

18740-59-5sc-239535
5 g
$403.00
(0)

Chlorotribenzylsilane is a versatile derivatization agent known for its ability to create stable covalent bonds with various nucleophiles. The presence of multiple benzyl groups enhances its lipophilicity, facilitating interactions with organic molecules and surfaces. Its unique structure allows for selective functionalization, driven by the reactivity of the chlorosilane moiety. This compound exhibits distinct reaction kinetics, enabling tailored modifications in complex chemical environments.

Chlorodimethyl(pentafluorophenyl)silane

20082-71-7sc-252585
5 ml
$245.00
(0)

Chlorodimethyl(pentafluorophenyl)silane is a versatile derivatization agent known for its strong electrophilic character, driven by the highly electronegative pentafluorophenyl group. This compound exhibits rapid reaction kinetics, enabling swift silanization of hydroxyl and amine functionalities. Its unique silane structure allows for robust covalent bonding, enhancing stability in modified substrates. The presence of fluorine atoms imparts distinctive electronic properties, facilitating selective interactions and improving the efficiency of chemical transformations.

N-Methyl-N,O-bis(trimethylsilyl)hydroxylamine

22737-33-3sc-295772
sc-295772A
1 ml
5 ml
$189.00
$630.00
(0)

N-Methyl-N,O-bis(trimethylsilyl)hydroxylamine is a versatile derivatization agent known for its ability to form stable silyl derivatives through selective reactions with hydroxyl and amine groups. Its trimethylsilyl moieties enhance solubility and volatility, facilitating easier analysis in various chromatographic techniques. The compound's unique reactivity profile allows for rapid and efficient derivatization, improving detection sensitivity and specificity in complex mixtures.

Boron tribromide dimethyl sulfide complex

29957-59-3sc-255004
25 g
$176.00
(0)

Boron tribromide dimethyl sulfide complex serves as a potent derivatization agent, effectively engaging with a range of functional groups through Lewis acid-base interactions. Its unique ability to activate electrophilic sites enhances reaction kinetics, promoting swift transformations. The complex's distinctive coordination chemistry allows for selective derivatization, yielding stable products that improve analytical resolution. This agent's physical properties, including its solubility in organic solvents, further facilitate its application in various analytical methodologies.

Dibenzyl dicarbonate

31139-36-3sc-252683
5 g
$210.00
(0)

Dibenzyl dicarbonate acts as a versatile derivatization agent, primarily through its ability to form stable carbonate esters. Its reactivity is characterized by the selective acylation of nucleophilic sites, which enhances the stability and detectability of target compounds. The compound's unique steric and electronic properties facilitate rapid reaction kinetics, allowing for efficient transformations. Additionally, its solubility in organic solvents supports diverse analytical techniques, making it a valuable tool in chemical analysis.