Date published: 2025-10-18

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Chloro(3-cyanopropyl)dimethylsilane (CAS 18156-15-5)

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Alternate Names:
(3-Cyanopropyl)dimethylchlorosilane
CAS Number:
18156-15-5
Molecular Weight:
161.70
Molecular Formula:
C6H12ClNSi
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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Chloro(3-cyanopropyl)dimethylsilane is a versatile compound extensively employed in diverse scientific research applications. It is a colorless liquid characterized by a strong odor and serves as an essential reagent in organic synthesis. Belonging to the silyl ether family, Chloro(3-cyanopropyl)dimethylsilane primarily functions as a protective agent for alcohols, amines, and carboxylic acids. Its applications span across various domains, including catalysis for different reactions, production of polymers and other materials, as well as synthesis of peptides, nucleosides, and other organic compounds. The precise mechanism by which Chloro(3-cyanopropyl)dimethylsilane operates remains incompletely understood. Nevertheless, it is hypothesized that the silyl ether group attached to Chloro(3-cyanopropyl)dimethylsilane acts as a safeguarding entity for the functional group it is associated with. Consequently, this shield prevents the functional group from interacting with other molecules during the reaction. Additionally, the cyano group within Chloro(3-cyanopropyl)dimethylsilane can function as a nucleophile, enabling it to react with electrophiles involved in the reaction.


Chloro(3-cyanopropyl)dimethylsilane (CAS 18156-15-5) References

  1. Cyano bonded silica monolith--development of an in situ modification method for analytical scale columns.  |  Soliven, A., et al. 2010. J Chromatogr A. 1217: 6085-91. PMID: 20732687
  2. Investigating retention characteristics of a mixed-mode stationary phase and the enhancement of monolith selectivity for high-performance liquid chromatography.  |  Bassanese, DN., et al. 2014. J Sep Sci. 37: 1937-43. PMID: 24824418
  3. Influence of the Nature of Self-Assembled Monolayers on Their Reactivity under Ionizing Radiation: A Solid-State NMR Study  |  S. Le Caër*†, F. Brunet‡, C. Chatelain†, L. Ladevie†, D. Durand§, V. Dauvois§, J. Ph. Renault†, and T. Charpentier‡. 2013. J. Phys. Chem. C. 117: 23258–23271.
  4. Electrical characterization of Si-doped n-type α-Ga2O3 on sapphire substrates  |  Takayuki Uchida, Kentaro Kaneko & Shizuo Fujita. 2018. MRS Advances. 3: 171–177.
  5. Precise synthesis of linear polysiloxanes with a polar side-chain structure by organocatalytic controlled/living ring-opening polymerization of (3-cyanopropyl)pentamethylcyclotrisiloxane  |  Keita Fuchise, *a Kazuhiko Satoa and Masayasu Igarashi *a. 2021. Polym. Chem. 21: 3321-3331.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Chloro(3-cyanopropyl)dimethylsilane, 5 ml

sc-227602
5 ml
$58.00
US: Only available in the US