DENND1C Inhibitors
Chemical inhibitors of DENND1C can function by interfering with various intracellular pathways that are crucial for the protein's role in vesicle trafficking and membrane dynamics. For instance, Wortmannin and LY294002 exert their inhibitory effects by targeting phosphoinositide 3-kinases (PI3K). This inhibition curtails the downstream signaling required for vesicle formation and trafficking, which are processes involving DENND1C. Similarly, dynamin, a GTPase integral to the scission of clathrin-coated vesicles, is the target of Dynasore and MiTMAB. By hindering dynamin's GTPase activity, these inhibitors can disrupt the endocytic processes that are facilitated by DENND1C. Paclitaxel and Nocodazole, which affect the stability of microtubules, alter intracellular transport and vesicle localization, thereby impacting the functional role of DENND1C. Paclitaxel (Taxol) stabilizes microtubules, whereas Nocodazole leads to their depolymerization, both resulting in the impairment of microtubule-dependent trafficking.
Furthermore, Monensin and Brefeldin A disrupt intracellular ion gradients and Golgi apparatus function, respectively. Monensin's alteration of vesicular pH and ion concentrations can lead to impaired endosomal sorting, while Brefeldin A's inhibition of vesicular transport between the Golgi and endoplasmic reticulum can restrict the trafficking pathways linked with DENND1C. Genistein targets phosphorylation events within tyrosine kinase signaling pathways, which are essential for the endocytic and trafficking functions of DENND1C. Chlorpromazine interferes with clathrin-mediated endocytosis, thereby inhibiting the formation of clathrin-coated vesicles and indirectly affecting DENND1C's associated endocytic trafficking. The cytoskeleton is also a target; Latrunculin A and Jasplakinolide manipulate actin dynamics, which are vital for vesicle movement. Latrunculin A prevents actin polymerization, disrupting cytoskeletal structure, while Jasplakinolide stabilizes actin filaments, both leading to a disruption of DENND1C-dependent trafficking mechanisms.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a specific covalent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in signaling pathways relevant to vesicle trafficking and membrane dynamics. Inhibition of PI3K can suppress the activation of downstream effectors that DENND1C might interact with during endocytic processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another potent inhibitor of PI3K. By inhibiting PI3K activity, LY294002 would decrease the phosphatidylinositol (3,4,5)-trisphosphate (PIP3) levels, potentially disrupting the membrane trafficking pathways that are associated with DENND1C function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a non-competitive inhibitor of the GTPase dynamin, which is critical for the scission of clathrin-coated vesicles from the plasma membrane. Inhibition of dynamin function can indirectly inhibit DENND1C by disrupting vesicular trafficking processes that DENND1C is involved in. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel (Taxol) stabilizes microtubules, thereby inhibiting their dynamic instability. Microtubule dynamics are crucial for intracellular transport and localization of vesicles. Stabilized microtubules can disrupt these processes, potentially leading to the functional inhibition of DENND1C's role in vesicle trafficking. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, leading to microtubule depolymerization. This collapse of the microtubule network can hinder vesicular transport and localization, which could indirectly inhibit DENND1C by disrupting its associated trafficking pathways. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that disrupts transmembrane ion gradients and vesicular pH. Altered ion gradients and pH can affect endosomal sorting and trafficking, indirectly inhibiting the function of DENND1C, which is involved in endocytic trafficking. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus, leading to an inhibition of vesicular transport between the Golgi and the endoplasmic reticulum. This disruption can indirectly inhibit DENND1C by affecting the trafficking pathways that DENND1C is associated with. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can interfere with phosphorylation events critical for intracellular signaling pathways. By inhibiting these signaling pathways, Genistein can disrupt processes that are essential for DENND1C's function in vesicle formation and trafficking. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine is known to inhibit clathrin-mediated endocytosis by preventing the assembly of clathrin at the plasma membrane. By inhibiting clathrin-coated vesicle formation, Chlorpromazine can indirectly inhibit the function of DENND1C, which is implicated in endocytic vesicle trafficking. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization, leading to cytoskeletal disruption. Since cytoskeletal elements are essential for vesicular movement and localization, Latrunculin A can indirectly inhibit DENND1C by disrupting the actin cytoskeleton-dependent trafficking pathways. | ||||||