Denaturants
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanidine Hydrochloride | 50-01-1 | sc-202637 sc-202637A sc-202637B | 100 g 1 kg 25 kg | $61.00 $310.00 $1975.00 | 1 | |
Guanidine Hydrochloride acts as a potent denaturant by disrupting hydrogen bonds and hydrophobic interactions within proteins, leading to their unfolding. Its high solubility in water enhances its ability to penetrate protein structures, facilitating the exposure of hydrophobic regions. This denaturation process is characterized by a rapid kinetic profile, allowing for swift alterations in protein conformation, which can significantly affect subsequent biochemical assays and interactions. | ||||||
Guanidine Thiocyanate | 593-84-0 | sc-202638 sc-202638A sc-202638B sc-202638C | 100 g 500 g 1 kg 25 kg | $91.00 $219.00 $316.00 $4382.00 | 5 | |
Guanidine Thiocyanate serves as an effective denaturant by destabilizing protein structures through the disruption of ionic and hydrophobic interactions. Its unique ability to form strong solvation shells around proteins enhances solubility and promotes unfolding. The compound's high affinity for thiol groups can lead to the modification of disulfide bonds, further contributing to protein denaturation. This process occurs through a gradual kinetic pathway, allowing for controlled alterations in protein conformation. | ||||||
Guanidine Hydrobromide | 19244-98-5 | sc-391466 | 5 g | $286.00 | ||
Guanidine Hydrobromide acts as a potent denaturant by interfering with hydrogen bonding and electrostatic interactions within proteins. Its strong chaotropic properties disrupt the ordered structure of water, enhancing protein solubility and promoting unfolding. The compound's ability to interact with polar and nonpolar regions of proteins facilitates a rapid denaturation process, leading to significant conformational changes. This unique behavior allows for effective manipulation of protein stability and structure. | ||||||
IGEPAL CA-630 | 9002-93-1 | sc-280818 sc-280818A | 25 ml 250 ml | $41.00 $63.00 | 3 | |
IGEPAL CA-630 serves as an effective denaturant by disrupting hydrophobic interactions and altering the solvation environment of proteins. Its nonionic surfactant properties enable it to reduce surface tension, promoting protein unfolding and aggregation. The compound's amphiphilic nature allows it to interact with both polar and nonpolar regions, facilitating the destabilization of protein structures. This unique behavior enhances the accessibility of reactive sites, influencing protein dynamics and stability. | ||||||
Urea-15N1 | sc-506183 | 1 g | $3756.00 | |||
Urea-15N1 serves as a potent denaturant, disrupting protein structures through its unique hydrogen bonding capabilities. The presence of the nitrogen isotope alters the electronic environment, enhancing interactions with polar and non-polar regions of biomolecules. This compound facilitates the unfolding of proteins by destabilizing secondary and tertiary structures, promoting exposure of hydrophobic residues. Its distinct isotopic signature also aids in elucidating protein dynamics and conformational changes during denaturation. | ||||||