δ-FR inhibitors, short for delta-Fatty Acid Reductase inhibitors, belong to a specific chemical class designed to target and modulate a critical enzyme involved in lipid metabolism within various biological organisms. These inhibitors primarily function by impeding the activity of the delta-Fatty Acid Reductase (δ-FR) enzyme, which is responsible for catalyzing the conversion of fatty acids into their corresponding alcohols. This enzymatic process plays a pivotal role in the biosynthesis of lipids, which are fundamental components of cell membranes and serve as energy storage molecules. δ-FR inhibitors are designed to interfere with this enzymatic reaction, thereby affecting the production of lipid molecules in cells.
Chemically, δ-FR inhibitors are characterized by their ability to selectively bind to the active site of the δ-FR enzyme, disrupting its catalytic function. By doing so, they alter the balance of lipid synthesis in the cell, which can have a profound impact on various physiological processes. Researchers have been particularly interested in the development of δ-FR inhibitors due to their implications in fields such as agriculture and biotechnology. By modulating lipid metabolism in specific organisms, these inhibitors could be used to control and manipulate lipid content, leading to improvements in crop yield, biofuel production, and the development of novel industrial applications. Additionally, they may hold promise in scientific research as valuable tools for studying lipid metabolism and its broader biological implications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram, a phosphodiesterase inhibitor, may elevate cAMP levels, which indirectly can alter the expression of various genes including those related to δ-FR. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
As a NF-κB inhibitor, curcumin can modulate inflammatory pathways and may influence the expression of genes, potentially impacting δ-FR levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a SIRT1 activator, may have a role in epigenetic regulation, potentially altering the expression profile of various genes, including δ-FR. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
This compound is a JNK inhibitor, which can affect AP-1 activity, a transcription factor complex where Fos proteins are components, possibly affecting δ-FR expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
By inhibiting the MAPK/ERK pathway, PD98059 could impact transcription factor activity and thereby reduce δ-FR protein expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This PI3K inhibitor may influence a variety of cellular processes, including protein synthesis and gene expression, which could affect δ-FR levels. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor and could modulate stress-responsive pathways, possibly leading to altered δ-FR expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane may exert its effects through NRF2 pathway activation, potentially influencing the transcription of different genes, including those encoding δ-FR. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine chloride is a PKC inhibitor, and PKC is implicated in various signaling pathways that can govern gene expression and protein synthesis, affecting δ-FR. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin is known to modulate GABAergic signaling and might influence neuronal activity and gene expression patterns, potentially affecting δ-FR levels. | ||||||