Date published: 2026-1-11

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δ-FR Inhibitors

δ-FR inhibitors, short for delta-Fatty Acid Reductase inhibitors, belong to a specific chemical class designed to target and modulate a critical enzyme involved in lipid metabolism within various biological organisms. These inhibitors primarily function by impeding the activity of the delta-Fatty Acid Reductase (δ-FR) enzyme, which is responsible for catalyzing the conversion of fatty acids into their corresponding alcohols. This enzymatic process plays a pivotal role in the biosynthesis of lipids, which are fundamental components of cell membranes and serve as energy storage molecules. δ-FR inhibitors are designed to interfere with this enzymatic reaction, thereby affecting the production of lipid molecules in cells.

Chemically, δ-FR inhibitors are characterized by their ability to selectively bind to the active site of the δ-FR enzyme, disrupting its catalytic function. By doing so, they alter the balance of lipid synthesis in the cell, which can have a profound impact on various physiological processes. Researchers have been particularly interested in the development of δ-FR inhibitors due to their implications in fields such as agriculture and biotechnology. By modulating lipid metabolism in specific organisms, these inhibitors could be used to control and manipulate lipid content, leading to improvements in crop yield, biofuel production, and the development of novel industrial applications. Additionally, they may hold promise in scientific research as valuable tools for studying lipid metabolism and its broader biological implications.

SEE ALSO...

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rolipram

61413-54-5sc-3563
sc-3563A
5 mg
50 mg
$77.00
$216.00
18
(1)

Rolipram, a phosphodiesterase inhibitor, may elevate cAMP levels, which indirectly can alter the expression of various genes including those related to δ-FR.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

As a NF-κB inhibitor, curcumin can modulate inflammatory pathways and may influence the expression of genes, potentially impacting δ-FR levels.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol, a SIRT1 activator, may have a role in epigenetic regulation, potentially altering the expression profile of various genes, including δ-FR.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

This compound is a JNK inhibitor, which can affect AP-1 activity, a transcription factor complex where Fos proteins are components, possibly affecting δ-FR expression.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

By inhibiting the MAPK/ERK pathway, PD98059 could impact transcription factor activity and thereby reduce δ-FR protein expression.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

This PI3K inhibitor may influence a variety of cellular processes, including protein synthesis and gene expression, which could affect δ-FR levels.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 is a p38 MAPK inhibitor and could modulate stress-responsive pathways, possibly leading to altered δ-FR expression.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

DL-Sulforaphane may exert its effects through NRF2 pathway activation, potentially influencing the transcription of different genes, including those encoding δ-FR.

Chelerythrine chloride

3895-92-9sc-3547
sc-3547A
5 mg
25 mg
$90.00
$317.00
17
(1)

Chelerythrine chloride is a PKC inhibitor, and PKC is implicated in various signaling pathways that can govern gene expression and protein synthesis, affecting δ-FR.

Wogonin, S. baicalensis

632-85-9sc-203313
10 mg
$200.00
8
(1)

Wogonin is known to modulate GABAergic signaling and might influence neuronal activity and gene expression patterns, potentially affecting δ-FR levels.