Date published: 2025-9-9

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DAPK Inhibitors

Death-associated protein kinase (DAPK) is a serine/threonine kinase that plays a pivotal role in the regulation of programmed cell death or apoptosis. DAPK signaling is involved in various cellular processes, including autophagy, cell motility, and the immune response. The activation of DAPK typically occurs through dephosphorylation at a specific serine residue, leading to its catalytic activation. Once activated, DAPK can phosphorylate a range of substrates, thereby transmitting apoptotic signals. This kinase is also known for its involvement in the response to cellular stress, such as DNA damage and oxidative stress. Dysregulation of DAPK signaling has been implicated in the development of several diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Targeting Death-associated protein kinase (DAPK) for disruption or inhibition is of significant interest in various research fields, especially for understanding and manipulating apoptosis and related cellular processes. Small molecule inhibitors of DAPK have been developed, with some exhibiting specificity for DAPK, while others are broad-spectrum kinase inhibitors affecting multiple targets including DAPK.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

[4-[[5-Chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone

1351758-81-0sc-505086
100 mg
$11500.00
(0)

This compound is a potent and selective inhibitor of Death-associated protein kinase (DAPK) family members. It has demonstrated the ability to interfere with Death-associated protein kinase (DAPK)-mediated signaling pathways, making it a valuable tool for studying the functions of these kinases.

STO-609

52029-86-4sc-507444
5 mg
$140.00
(0)

While primarily known as a CaMKK inhibitor, STO-609 has also been shown to inhibit Death-associated protein kinases. It interferes with the interaction between Death-associated protein kinase (DAPK) and its binding partner, enabling researchers to explore DAPK-related processes.

BML-275

866405-64-3sc-200689
sc-200689A
5 mg
25 mg
$94.00
$348.00
69
(1)

Although primarily known as an AMP-activated protein kinase (AMPK) inhibitor, Compound C has also been reported to inhibit DAPKs.

AZD7762

860352-01-8sc-364423
2 mg
$107.00
(1)

While primarily known as a checkpoint kinase 1 (Chk1) inhibitor, AZD7762 has been reported to have inhibitory effects on DAPKs. Its kinase-targeting profile adds to its potential utility.

LDN-214117

1627503-67-6sc-507451
5 mg
$165.00
(0)

LDN-214117 has been identified as a dual inhibitor of multiple kinases, including DAPKs. Its effects on kinase signaling offer opportunities to investigate DAPK functions.

Selumetinib

606143-52-6sc-364613
sc-364613A
sc-364613B
sc-364613C
sc-364613D
5 mg
10 mg
100 mg
500 mg
1 g
$28.00
$80.00
$412.00
$1860.00
$2962.00
5
(1)

Originally developed as a MEK inhibitor, it has been found to have inhibitory effects on DAPK.

Roscovitine

186692-46-6sc-24002
sc-24002A
1 mg
5 mg
$92.00
$260.00
42
(2)

A cyclin-dependent kinase (CDK) inhibitor with broad activity, including inhibition of DAPK.

Harmine

442-51-3sc-202644
sc-202644A
sc-202644B
sc-202644C
sc-202644D
sc-202644E
sc-202644F
250 mg
500 mg
1 g
10 g
50 g
100 g
500 g
$52.00
$102.00
$124.00
$540.00
$1438.00
$2560.00
$11230.00
2
(2)

An alkaloid with various pharmacological activities, including inhibition of DAPK.

NH125

278603-08-0sc-203037
5 mg
$187.00
1
(1)

Originally identified as a eukaryotic elongation factor-2 kinase inhibitor, it also exhibits inhibitory effects on DAPK.