DDX23 Inhibitors

DDX23 inhibitors belong to a class of chemical compounds designed to target and inhibit the activity of the DDX23 protein. DDX23, also known as RNA helicase A (RHA), is a member of the DEAD-box RNA helicase family. These enzymes play a crucial role in RNA metabolism by unwinding RNA duplexes and facilitating various aspects of RNA processing, including transcription, splicing, translation, and RNA degradation. DDX23, in particular, is known to be involved in RNA splicing, export, and ribosome biogenesis. It functions by unwinding RNA secondary structures, allowing for the proper formation and modification of RNA molecules, which is essential for the regulation of gene expression.

DDX23 inhibitors are designed to specifically block or reduce the activity of DDX23, disrupting its role in RNA metabolism. These inhibitors can act by binding to the DDX23 protein and interfering with its helicase activity, ultimately impeding its ability to unwind RNA molecules. By targeting DDX23, researchers aim to investigate the functional consequences of inhibiting this particular RNA helicase, shedding light on the intricate mechanisms governing RNA processing and gene regulation. Understanding the role of DDX23 and its inhibition through the development of DDX23 inhibitors is critical for unraveling the complexities of RNA biology, which can have broad implications in various fields, including molecular biology, genetics, and cell biology.