Date published: 2025-11-25

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DCDC5 Inhibitors

DCDC5 Inhibitors influence the functional activity of DCDC5 through various cellular signaling pathways, although they are not direct inhibitors of DCDC5 itself. For instance, Phorbol 12-myristate 13-acetate (PMA) and Gö6983, both influence PKC activity. PKC is a kinase with a broad spectrum of substrates including proteins that could interact with or regulate DCDC5. By modifying PKC activity, these compounds can affect DCDC5 indirectly. PMA activation and Gö6983 inhibition of PKC could alter the phosphorylation and function of DCDC5-associated proteins, thereby modulating DCDC5's activity in the cell. Similarly, Staurosporine, a broad-spectrum kinase inhibitor, can inhibit PKC and consequently affect the phosphorylation status of proteins associated with DCDC5, potentially leading to decreased DCDC5 activity. Other inhibitors act on different aspects of cellular signaling that can indirectly impact DCDC5. LY294002 and U0126 target the PI3K/Akt and MEK/ERK pathways, respectively, which are involved in regulating a multitude of cellular functions, including those that may govern the activity of DCDC5. The PI3K/Akt pathway is crucial for cell survival and metabolism, and its inhibition by LY294002 could affect DCDC5 indirectly by altering thephosphorylation status of proteins interacting with DCDC5. U0126, by inhibiting the ERK pathway, could similarly change the phosphorylation landscape of proteins that regulate or are regulated by DCDC5, leading to reduced DCDC5 activity. Rapamycin and Brefeldin A target fundamental cellular processes such as mTOR signaling and protein trafficking. Rapamycin's inhibition of mTOR might affect the synthesis or degradation of DCDC5 or its associated proteins, while Brefeldin A's disruption of ARF1-mediated transport could impair the proper localization of proteins necessary for DCDC5's function.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates protein kinase C (PKC), which can lead to the phosphorylation of proteins that interact with DCDC5, potentially altering its localization or stability within the cell.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

Staurosporine is a potent PKC inhibitor. PKC has various cellular targets and inhibiting PKC can lead to reduced phosphorylation of DCDC5-associated proteins, thereby potentially inhibiting DCDC5 function.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a PI3K inhibitor. PI3K signaling is crucial for many cellular processes, and its inhibition can affect the Akt pathway, which could alter the phosphorylation status of proteins that regulate DCDC5 function.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin inhibits mTOR, which is part of a pathway that can regulate protein synthesis and turnover. Inhibiting mTOR can influence the degradation or synthesis of proteins that interact with DCDC5, thus indirectly inhibiting its function.

Wnt-C59

1243243-89-1sc-475634
sc-475634A
sc-475634B
5 mg
10 mg
50 mg
$210.00
$320.00
$1250.00
1
(0)

Wnt-C59 is an inhibitor of Wnt production. While Wnt is not to be inhibited directly, the Wnt signaling pathway can regulate processes that may affect DCDC5 function. Inhibiting Wnt can change the cellular milieu in which DCDC5 operates.

Cyclopamine

4449-51-8sc-200929
sc-200929A
1 mg
5 mg
$92.00
$204.00
19
(1)

Cyclopamine inhibits the Hedgehog signaling pathway. Hedgehog can regulate the expression of genes that may interact with DCDC5. Inhibition of Hedgehog signaling could indirectly inhibit DCDC5 by affecting these interactions.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

PD98059 is an MEK inhibitor, which can down-regulate the ERK pathway. The ERK pathway can modulate the activity of numerous proteins, potentially including those that interact with or regulate DCDC5.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$30.00
$52.00
$122.00
$367.00
25
(3)

Brefeldin A disrupts protein transport by inhibiting the exchange of protein ADP-ribosylation factor 1 (ARF1). This can lead to mislocalization of proteins that are necessary for DCDC5 to function properly.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126 is another MEK inhibitor that can suppress the ERK pathway. Inhibition of ERK signaling might influence the phosphorylation status and function of proteins associated with DCDC5.

Gö 6983

133053-19-7sc-203432
sc-203432A
sc-203432B
1 mg
5 mg
10 mg
$103.00
$293.00
$465.00
15
(1)

Gö6983 is a PKC inhibitor with a broad range of activity. By inhibiting PKC, it could reduce the phosphorylation and thus the activity of proteins that interact with or regulate DCDC5.