Date published: 2026-2-8

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DAZL Inhibitors

DAZL inhibitors represent a class of chemical compounds designed to modulate the activity of the Deleted in Azoospermia-Like (DAZL) protein, a crucial regulator of germ cell development. The DAZL protein, belonging to the DAZ family of RNA-binding proteins, plays a pivotal role in germ cell specification and differentiation, particularly in the development of oocytes and sperm. The inhibition of DAZL by specific inhibitors is aimed at gaining a deeper understanding of the intricate molecular mechanisms underlying germ cell development and maturation. The structural design of DAZL inhibitors is meticulously crafted to interact with the protein's binding sites, disrupting its normal function. By impeding the activity of DAZL, these inhibitors offer a unique tool for researchers to investigate the intricate network of molecular events that govern germ cell development. Furthermore, the development of potent and selective DAZL inhibitors holds promise for unraveling the complexities of reproductive biology, potentially shedding light on novel targets for intervention in conditions related to infertility or aberrant germ cell development. As research progresses in this area, a more comprehensive understanding of the specific roles played by DAZL in cellular processes may emerge, providing insights that could have implications for various aspects of reproductive biology and potentially inform future avenues for scientific exploration.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Spautin-1

1262888-28-7sc-507306
10 mg
$168.00
(0)

Inhibits USP13 and USP10, potentially decreasing deubiquitination and increasing protein degradation.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

Proteasome inhibitor that could lead to increased degradation of proteins, including DAZL.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$51.00
$231.00
$523.00
63
(1)

DNA damage agent that can disrupt cellular division and therefore germ cell development.

Mitomycin C

50-07-7sc-3514A
sc-3514
sc-3514B
2 mg
5 mg
10 mg
$66.00
$101.00
$143.00
85
(5)

Crosslinks DNA and could interfere with rapidly dividing cells, including germ cells.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

A DNA methyltransferase inhibitor that can alter gene expression, including that of DAZL.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

Histone deacetylase inhibitor, altering chromatin structure and gene expression.

Nutlin-3

548472-68-0sc-45061
sc-45061A
sc-45061B
1 mg
5 mg
25 mg
$62.00
$225.00
$779.00
24
(1)

Disrupts p53-MDM2 interaction, potentially affecting cell cycle and germ cell development.

Taxol

33069-62-4sc-201439D
sc-201439
sc-201439A
sc-201439E
sc-201439B
sc-201439C
1 mg
5 mg
25 mg
100 mg
250 mg
1 g
$41.00
$74.00
$221.00
$247.00
$738.00
$1220.00
39
(2)

Stabilizes microtubules, affecting cell division and could indirectly influence DAZL function.

Roscovitine

186692-46-6sc-24002
sc-24002A
1 mg
5 mg
$94.00
$265.00
42
(2)

Cyclin-dependent kinase inhibitor, potentially affecting cell cycle regulation of germ cells.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

mTOR inhibitor which could affect germ cell development and indirectly DAZL function.