DAT Inhibitors
Items 11 to 16 of 16 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Talsupram hydrochloride | 25487-28-9 | sc-364753 sc-364753A | 10 mg 50 mg | $185.00 $756.00 | ||
a selective serotonin reuptake inhibitor (SSRI) that targets the serotonin transporter (SLC6A4). By blocking the reuptake of serotonin, it increases serotonin levels in the synapse, potentially influencing mood regulation. Its impact on the dopamine transporter (DAT) is less pronounced compared to its effect on SLC6A4. | ||||||
JHW 007 hydrochloride | 202645-74-7 | sc-362752 sc-362752A | 10 mg 50 mg | $183.00 $771.00 | ||
JHW 007 hydrochloride acts as a selective dopamine transporter (DAT) inhibitor, characterized by its unique ability to form stable interactions with the transporter’s binding site. This compound exhibits distinct kinetic profiles, influencing the rate of dopamine transport and reuptake. Its structural features allow for specific conformational changes in the DAT, which can modulate the transporter's activity and alter synaptic dopamine levels, thereby impacting overall neurotransmission. | ||||||
Safinamide mesylate | 202825-46-5 | sc-364754 sc-364754A | 5 mg 25 mg | $90.00 $278.00 | ||
Safinamide mesylate inhibits monoamine oxidase B (MAO-B), a key enzyme that breaks down neurotransmitters like dopamine. By limiting this breakdown, it raises dopamine levels in the brain, contributing to its effects. Its interaction with the dopamine transporter (DAT) isn't the primary mode of action; it mainly affects neurotransmitter metabolism via MAO-B inhibition. | ||||||
(S,S)-Hydroxy Bupropion | 192374-14-4 | sc-212825 sc-212825A | 1 mg 10 mg | $360.00 $2290.00 | ||
(S,S)-Hydroxybupropion, a metabolite of bupropion, mildly inhibits the dopamine transporter (DAT). By impeding dopamine reuptake, it raises dopamine levels in the synapse, potentially affecting mood. Its inhibition of DAT is less potent than in drugs like cocaine. | ||||||
Desipramine hydrochloride | 58-28-6 | sc-200158 sc-200158A | 100 mg 1 g | $66.00 $117.00 | 6 | |
Desipramine hydrochloride functions as a dopamine transporter (DAT) modulator, exhibiting a high affinity for the transporter’s binding domain. Its unique molecular structure facilitates specific hydrogen bonding and hydrophobic interactions, enhancing binding stability. This compound influences DAT conformational dynamics, leading to altered transport kinetics. The distinct electronic properties of desipramine enable it to affect the electrochemical gradients across neuronal membranes, thereby impacting dopamine flux and signaling pathways. | ||||||
7-Hydroxy Granisetron-d3 Hydrochloride | 2124272-03-1 | sc-495587 | 0.5 mg | $402.00 | ||
7-Hydroxy Granisetron-d3 Hydrochloride acts as a dopamine transporter (DAT) modulator, characterized by its ability to engage in selective molecular interactions. Its unique stereochemistry allows for enhanced binding affinity, promoting specific electrostatic interactions with DAT. This compound influences the allosteric modulation of the transporter, altering its conformational states and transport efficiency. Additionally, its isotopic labeling provides insights into metabolic pathways and reaction kinetics, facilitating advanced studies in neurochemical dynamics. | ||||||