Date published: 2026-5-28

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DAGL Inhibitors

Santa Cruz Biotechnology now offers a broad range of DAGL Inhibitors for use in various applications. Diacylglycerol lipase (DAGL) is an enzyme that plays a critical role in the biosynthesis of 2-arachidonoylglycerol (2-AG), a key endocannabinoid involved in various physiological processes, including synaptic signaling, immune response, and inflammation. DAGL Inhibitors are essential tools in scientific research, enabling researchers to explore the functions of DAGL and its role in the endocannabinoid system. By inhibiting DAGL activity, scientists can study how the reduction in 2-AG levels affects intracellular signaling pathways, providing insights into the enzyme's involvement in neural communication, pain modulation, and metabolic regulation. These inhibitors are widely used in studies focused on understanding the mechanisms underlying endocannabinoid signaling and how disruptions in this pathway can lead to various physiological and pathological outcomes. Additionally, DAGL Inhibitors are valuable in research exploring the broader implications of lipid signaling in cellular processes, including how DAGL-related pathways intersect with other signaling networks that regulate cellular homeostasis and function. The availability of these inhibitors has significantly advanced research in fields such as neurobiology, immunology, and biochemistry, offering researchers powerful tools to dissect the complex roles of DAGL in cellular and molecular biology. By facilitating the precise modulation of DAGL activity, these inhibitors are indispensable for advancing our understanding of lipid-mediated signaling pathways and their impact on health and disease. View detailed information on our available DAGL Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Lipase Inhibitor, THL

96829-58-2sc-203108
50 mg
$52.00
7
(1)

THL, a lipase inhibitor, operates as a DAGL by selectively binding to the enzyme's active site, altering its conformation and hindering substrate binding. This compound exhibits unique hydrophobic interactions that enhance its specificity, while its ability to form transient complexes with lipid substrates influences reaction kinetics. Additionally, THL's distinct steric properties allow it to modulate lipid metabolism pathways, providing insights into enzymatic regulation and lipid signaling dynamics.

RHC-80267

83654-05-1sc-222251
10 mg
$77.00
1
(1)

RHC-80267 functions as a DAGL by engaging in specific non-covalent interactions with the enzyme, stabilizing a unique conformation that affects substrate accessibility. Its structural features promote selective binding, leading to altered catalytic efficiency. The compound's hydrophilic and hydrophobic regions facilitate distinct solubility profiles, influencing its distribution in lipid environments. Furthermore, RHC-80267's kinetic behavior reveals insights into enzyme-substrate dynamics and regulatory mechanisms in lipid signaling pathways.