D830046C22Rik Inhibitors
Gpr146, a G protein-coupled receptor (GPCR) primarily located in the plasma membrane, is a multifaceted player in cellular processes, contributing significantly to diverse physiological functions. Predicted to enable microtubule binding activity and microtubule motor activity, Gpr146 participates in critical processes such as the establishment of cell polarity, positive regulation of cell-cell adhesion, and ureteric bud invasion. The gene exhibits expression in various structures, including the alimentary system, central nervous system, genitourinary system, hindlimb interdigital region, and sensory organs. Its orthologous relationship with the human GPR146 emphasizes its evolutionary conservation and potential importance across species.
In the context of Gpr146's inhibition, a range of chemical compounds target its signaling pathways, influencing the receptor's functional roles. These mechanisms of inhibition include interference with the Rho/ROCK signaling pathway, modulation of TGF-β signaling, disruption of Gαi protein-mediated GPCR signaling, and inhibition of crucial cascades such as MAPK/ERK and PI3K/Akt pathways. Additionally, inhibitors targeting Wnt and Hedgehog pathways showcase the interconnectedness of Gpr146 with broader cellular signaling networks. The diverse chemical interventions underscore the intricate regulatory role Gpr146 plays in cellular processes, and the varying mechanisms of inhibition highlight the complexity of modulating GPCRs within intricate signaling networks. It becomes evident that Gpr146's influence is not confined to a singular pathway but is intricately woven into a network of interconnected signaling cascades, reflecting its importance in maintaining cellular homeostasis and contributing to developmental processes. Understanding the functional significance of Gpr146 and its modulation provides insights into the dynamic nature of GPCR signaling in cellular physiology. The intricacies of Gpr146's involvement in microtubule dynamics, cell adhesion, and organ development underscore its relevance in fundamental biological processes. The chemical interventions explored in inhibition studies illuminate the potential for targeted manipulation of Gpr146 signaling to dissect and understand its precise role in cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $33.00 $87.00 $168.00 $253.00 $496.00 $910.00 | 5 | |
Fasudil, a Rho-kinase inhibitor, interferes with the Rho/ROCK signaling pathway. Gpr146, a G protein-coupled receptor in the plasma membrane, may be indirectly inhibited by Fasudil through modulation of downstream Rho/ROCK signaling, affecting cellular processes linked to Gpr146 function at the plasma membrane. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 inhibits the TGF-β receptor, impacting the TGF-β pathway. Gpr146, situated in the plasma membrane, may be indirectly influenced by SB-431542 through interference with TGF-β signaling, potentially affecting cellular processes associated with Gpr146 function. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin inhibits Gαi protein signaling, affecting G protein-coupled receptor (GPCR) signaling. Gpr146, a GPCR located in the plasma membrane, may be directly inhibited by Pertussis Toxin, disrupting its coupling to Gαi proteins and influencing downstream cellular processes mediated by Gpr146 signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor, affecting the PI3K/Akt signaling pathway. Gpr146, situated in the plasma membrane, may be indirectly influenced by Wortmannin through interference with PI3K signaling, potentially affecting cellular processes linked to Gpr146 function and downstream signaling cascades. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine inhibits the Hedgehog signaling pathway. Gpr146, located in the plasma membrane, may be indirectly inhibited by Cyclopamine through interference with Hedgehog signaling, potentially influencing cellular processes associated with Gpr146 function and downstream events in the plasma membrane. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
Losartan, an Angiotensin II receptor blocker, modulates Angiotensin II signaling. Gpr146, involved in GPCR signaling, may be indirectly influenced by Losartan through modulation of Angiotensin II signaling, potentially affecting cellular processes associated with Gpr146 function at the plasma membrane. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV939 inhibits the Wnt pathway, interfering with Wnt signaling. Gpr146, situated in the plasma membrane, may be indirectly inhibited by XAV939 through interference with Wnt signaling, potentially affecting cellular processes linked to Gpr146 function and downstream events in the plasma membrane. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib, a JAK inhibitor, targets the JAK/STAT signaling pathway. Gpr146, located in the plasma membrane, may be indirectly influenced by Ruxolitinib through interference with JAK/STAT signaling, potentially impacting cellular processes associated with Gpr146 function and downstream signaling cascades. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
SQ22536 inhibits adenylate cyclase, affecting the cyclic AMP pathway. Gpr146, a GPCR, may be indirectly inhibited by SQ22536 through modulation of cAMP signaling, potentially affecting cellular processes linked to Gpr146 function and downstream events in the plasma membrane. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A, a calcineurin inhibitor, targets the calcineurin/NFAT signaling pathway. Gpr146, located in the plasma membrane, may be indirectly inhibited by Cyclosporin A through interference with calcineurin/NFAT signaling, potentially impacting cellular processes associated with Gpr146 function and downstream signaling cascades. | ||||||