Cytokeratin 19 Inhibitors
Cytokeratin 19 inhibitors belong to a class of compounds designed to selectively target the protein cytokeratin 19 (CK19), a member of the intermediate filament family of proteins found in epithelial cells. CK19 plays a crucial structural role in maintaining cell integrity and is involved in various cellular functions, including providing mechanical support, anchoring organelles, and participating in cell signaling pathways. Notably, CK19 is present in several types of epithelial tissues, including the liver, pancreas, and certain glands, contributing to the structural integrity of these tissues. CK19 inhibitors are meticulously crafted molecules engineered to interact with CK19, modulating its function or disrupting its role in cellular processes associated with cytoskeletal organization and cellular signaling pathways.
Chemically, CK19 inhibitors are designed to selectively bind to specific regions or functional domains of the CK19 protein, altering its structure or impeding its interactions with other cellular components. The molecular structure of these inhibitors is tailored to fit into the binding sites or active regions of CK19, aiming to interfere with its normal functions without substantially affecting other cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-FU is an agent that can inhibit DNA synthesis. By affecting rapidly dividing cells, it may down-regulate CK19 expression in certain cancer cells. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen can modulate estrogen receptor signaling, potentially affecting CK19 expression. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib targets the EGFR tyrosine kinase. EGFR signaling can influence CK19 expression, and its inhibition might down-regulate CK19. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine is a Hedgehog signaling pathway inhibitor. As this pathway can influence epithelial cell differentiation, it might affect CK19 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone, can modulate various signaling pathways and might down-regulate CK19 expression in certain cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can modulate various cellular pathways, potentially influencing CK19 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR signaling, which can influence protein synthesis and might down-regulate CK19. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits DNA synthesis, potentially affecting the expression of proteins like CK19 in rapidly dividing cells. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. By affecting protein turnover, it might influence CK19 stability and expression. | ||||||