cystatin SN Inhibitors
Inhibitors that would fall into the category of cystatin SN inhibitors would be molecules that can modulate the activity of cystatin SN. Since cystatin SN functions mainly as an inhibitor of cysteine proteases, compounds that indirectly influence cystatin SN are likely to do so by altering the activity or expression of these proteases.
Chemicals like E-64 or leupeptin inhibit the proteases directly, which might reduce the physiological need for cystatin SN inhibition. Others, such as odanacatib and K11777, are more specific for certain cathepsins and would thereby affect the protein's regulatory scope. Compounds such as MDL-28170 or Z-FA-FMK could impact broader protease activity and consequently influence the regulatory dynamics involving cystatin SN. These compounds do not interact with cystatin SN directly but could modulate the proteolytic environment in which cystatin SN operates.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64 is an irreversible cysteine protease inhibitor that could reduce the demand for cystatin SN's inhibitory function by directly inhibiting the proteases. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
A reversible inhibitor of certain serine and cysteine proteases, potentially compensating for cystatin SN's activity. | ||||||
Odanacatib | 603139-19-1 | sc-364675 sc-364675A sc-364675B | 5 mg 25 mg 250 mg | $214.00 $974.00 $1943.00 | 2 | |
Originally developed to inhibit cathepsin K, odanacatib might indirectly affect protease regulation by cystatin SN. | ||||||
K777 | 233277-99-1 | sc-507382 | 10 mg | $555.00 | ||
A potent inhibitor of cruzain and cathepsin L, which could influence the proteolytic pathways involving cystatin SN. | ||||||
MDL-28170 | 88191-84-8 | sc-201301 sc-201301A sc-201301B sc-201301C | 10 mg 50 mg 100 mg 500 mg | $68.00 $236.00 $438.00 $2152.00 | 20 | |
This calpain inhibitor could also affect other cysteine proteases and consequently modify the regulatory role of cystatin SN. | ||||||
Z-FA-FMK | 197855-65-5 | sc-201303 sc-201303A | 1 mg 5 mg | $125.00 $365.00 | 19 | |
A synthetic irreversible inhibitor of cysteine proteases, which could decrease the proteolytic breakdown where cystatin SN is a regulator. | ||||||
Allicin | 539-86-6 | sc-202449 sc-202449A | 1 mg 5 mg | $460.00 $1428.00 | 7 | |
Derived from garlic, allicin has been shown to have inhibitory effects on various cysteine proteases, which are regulated by cystatin SN. | ||||||