CYP2J2 Activators
The chemical class of CYP2J2 activators encompasses a range of compounds that can indirectly influence the activity of this cytochrome P450 enzyme. These activators do not interact directly with CYP2J2 but modulate its activity through various biochemical and physiological pathways. The class includes both endogenous substrates and exogenous compounds, highlighting the diverse mechanisms through which CYP2J2 activity can be modulated.
Fatty acids such as arachidonic acid, linoleic acid, and α-linolenic acid are key members of this class. As substrates of CYP2J2, their availability can dictate the enzyme's activity level. The metabolism of these fatty acids by CYP2J2 leads to the production of biologically active metabolites, emphasizing the role of substrate availability in enzyme regulation. On the other hand, compounds like prostaglandin E2, though not direct activators, influence CYP2J2 activity by modulating physiological pathways, such as inflammation, that can affect enzyme expression and function. Pharmaceutical agents, including phenobarbital, rifampicin, and clofibrate, represent another aspect of this class. These compounds influence CYP2J2 activity by affecting the expression levels of the enzyme, primarily through their interaction with nuclear receptors and modulation of transcriptional processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
As a substrate for CYP2J2, arachidonic acid can increase the enzyme's activity. Its metabolism by CYP2J2 leads to the formation of epoxyeicosatrienoic acids (EETs), which play a role in various physiological processes. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Another substrate for CYP2J2, linoleic acid can indirectly enhance the enzyme's activity through its metabolism into epoxygenase products, modulating cellular functions. | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $38.00 $115.00 | 2 | |
This fatty acid can be metabolized by CYP2J2, potentially increasing its activity through substrate availability. Its metabolism produces various metabolites involved in cellular signaling. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Though not a direct activator, PGE2 can modulate inflammatory responses, which may indirectly influence CYP2J2 expression or activity due to its role in inflammation-related pathways. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Known to induce certain P450 enzymes, rifampicin can potentially increase CYP2J2 expression through activation of nuclear receptors involved in P450 regulation. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
As a peroxisome proliferator-activated receptor (PPAR) agonist, clofibrate might influence CYP2J2 activity by modulating lipid metabolism pathways. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
This thiazolidinedione, a PPARγ agonist, may indirectly influence CYP2J2 activity through effects on lipid and glucose metabolism. | ||||||
Fluvastatin | 93957-54-1 | sc-279169 | 50 mg | $250.00 | ||
As a statin, fluvastatin can indirectly influence CYP2J2 activity by altering lipid metabolism pathways, potentially affecting CYP2J2 substrate availability. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
This calcium channel blocker can influence vascular functions and might indirectly affect CYP2J2 activity through its effects on blood flow and tissue perfusion. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid that can modulate cytochrome P450 expression, dexamethasone may indirectly influence CYP2J2 activity through its effects on inflammation and metabolism. | ||||||