Cyp2c67 Inhibitors
Chemical inhibitors of Cyp2c67 include a variety of compounds primarily recognized for their antifungal properties, but they share a common mechanism that enables them to inhibit the enzymatic activity of Cyp2c67. Compounds such as Miconazole, Ketoconazole, Fluconazole, Sulconazole, Clotrimazole, Tioconazole, Econazole, Voriconazole, and Itraconazole inhibit Cyp2c67 by binding to the heme group within the enzyme's active site. This interaction obstructs the necessary electron transfer for the catalytic cycle of Cyp2c67, which is essential for its function in metabolizing substrates. These inhibitors are direct antagonists to the active site of Cyp2c67, preventing substrate molecules from accessing the catalytic iron necessary for their transformation.
Furthermore, other non-antifungal chemical inhibitors such as Sertraline, Fluoxetine, and Paroxetine also act upon Cyp2c67 by competing with endogenous substrates for the active site. By occupying the space where substrates would typically bind, these chemicals directly inhibit the protein's normal metabolic activity. Their binding to the active site results in a blockade which prevents the processing of the enzyme's natural substrates, thereby inhibiting the overall function of Cyp2c67. Each of these chemicals, despite their primary uses in other contexts, exhibit an ability to bind to and inhibit Cyp2c67 by preventing the typical substrate-enzyme interactions that are critical for the enzyme's metabolic role.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Miconazole, an antifungal agent, can inhibit Cyp2c67 by binding to the heme group in the active site of the protein. This binding impedes the enzyme's ability to metabolize its endogenous substrates, leading to functional inhibition. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole interacts with Cyp2c67 by also targeting the heme group within the enzyme’s active site. This action disrupts the enzymatic activity of Cyp2c67 by preventing the binding and metabolism of its substrates. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $53.00 $84.00 | 14 | |
Fluconazole inhibits Cyp2c67 by binding to its heme iron, which is crucial for the enzymatic function of Cyp2c67. This binding directly inhibits the protein's metabolic activity by obstructing the necessary electron transfer for its catalytic cycle. | ||||||
Sulconazole | 61318-90-9 | sc-338599 | 100 mg | $1000.00 | 1 | |
Sulconazole can inhibit Cyp2c67 by directly binding to the enzyme’s active site, particularly the heme iron, thus interrupting the electron transfer necessary for Cyp2c67’s metabolic functions. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Clotrimazole inhibits Cyp2c67 by occupying its active site and physically blocking substrate access, which directly impedes the enzymatic activity of Cyp2c67. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Econazole inhibits Cyp2c67 by interacting with the heme group of the protein, disrupting the electron transfer process that is essential for the enzyme's catalytic activity, thus directly inhibiting the enzyme. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $76.00 $139.00 | 23 | |
Itraconazole can inhibit Cyp2c67 through binding to the enzyme's heme group, disrupting the normal catalytic cycle by preventing electron transfer, which is pivotal for enzymatic activity. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $312.00 | 9 | |
Fluoxetine inhibits Cyp2c67 by competing with endogenous substrates for binding to the active site of the enzyme, which results in direct inhibition of its metabolic function. | ||||||
Paroxetine | 61869-08-7 | sc-507527 | 1 g | $180.00 | ||
Paroxetine can act as an inhibitor of Cyp2c67 by binding to the enzyme's active site and preventing the access of natural substrates, thereby directly inhibiting the protein's enzymatic activity. | ||||||