Cyp2c54 Activators
Cyp2c54, a cytochrome P450 enzyme, exhibits dual epoxygenase activities towards arachidonic acid and linoleic acid, influencing eicosanoid synthesis and lipid metabolism. Located in the endoplasmic reticulum and membrane, Cyp2c54 plays a crucial role in arachidonic acid and linoleic acid metabolic processes. The activation of Cyp2c54 involves direct and indirect mechanisms mediated by diverse chemicals. Direct activators include Rifampicin, Lithium Carbonate, and Troleandomycin, which directly upregulate Cyp2c54 expression and enhance its epoxygenase activities towards arachidonic acid and linoleic acid. Indirect activators, such as GW7647, Clofibrate, and Troglitazone, modulate PPAR signaling pathways, influencing Cyp2c54 expression and activity. Additionally, chemicals like Fluconazole, Zafirlukast, and Terbinafine indirectly activate Cyp2c54 by affecting arachidonic acid and linoleic acid metabolic processes, triggering a stress response and increasing enzyme expression.
The general mechanisms of Cyp2c54 activation involve the modulation of its expression and activity through various pathways. PPAR agonists, such as GW7647 and Troglitazone, exert indirect effects by enhancing Cyp2c54 expression. Stress response inducers like Lithium Carbonate and Terbinafine activate Cyp2c54 by triggering cellular stress responses. Furthermore, direct activators like Rifampicin and Troleandomycin directly upregulate Cyp2c54 expression and enhance its epoxygenase activities, contributing to the synthesis of biologically active epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs). Overall, understanding the diverse chemical modulators of Cyp2c54 sheds light on potential strategies for manipulating its activity in the context of arachidonic acid and linoleic acid metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin, an antibiotic, directly activates Cyp2c54 by upregulating its expression and enhancing both arachidonic acid and linoleic acid epoxygenase activities. It influences cytochrome P450 pathways, promoting the synthesis of epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs) with anti-inflammatory and vasodilatory effects. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $49.00 $170.00 $267.00 $661.00 | 6 | |
GW7647, a PPARα agonist, serves as an indirect activator of Cyp2c54. By activating PPARα, it upregulates the expression of Cyp2c54, enhancing its arachidonic acid and linoleic acid epoxygenase activities. This contributes to the modulation of eicosanoid synthesis, influencing the production of epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs) with vasodilatory and anti-inflammatory properties. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $54.00 $84.00 | 14 | |
Fluconazole, an antifungal medication, indirectly activates Cyp2c54 by influencing arachidonic acid and linoleic acid metabolic processes. By modulating fungal cell membrane integrity, it triggers a stress response, leading to increased expression and activity of Cyp2c54. This results in enhanced epoxygenase activities and the production of epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs) with anti-inflammatory effects. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Clofibrate, a lipid-lowering agent, indirectly activates Cyp2c54 by modulating PPARα signaling. It upregulates the expression of Cyp2c54, enhancing its arachidonic acid and linoleic acid epoxygenase activities. This influences eicosanoid synthesis, promoting the production of epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs) with vasodilatory and anti-inflammatory properties. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Carbonate, a mood stabilizer, serves as a direct activator of Cyp2c54 by influencing arachidonic acid and linoleic acid metabolic processes. It triggers a cellular stress response, leading to increased expression and activity of Cyp2c54, enhancing its epoxygenase activities and the production of epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs) with anti-inflammatory and vasodilatory effects. | ||||||
Zafirlukast | 107753-78-6 | sc-204942 sc-204942A | 10 mg 100 mg | $37.00 $174.00 | 1 | |
Zafirlukast, a leukotriene receptor antagonist, indirectly activates Cyp2c54 by influencing arachidonic acid and linoleic acid metabolic processes. By blocking the effects of leukotrienes, it promotes the redirection of arachidonic acid and linoleic acid towards Cyp2c54-mediated epoxygenase pathways. This enhances the synthesis of epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs) with vasodilatory and anti-inflammatory properties. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
Gemfibrozil, a lipid-lowering agent, indirectly activates Cyp2c54 by modulating PPARα signaling. It upregulates the expression of Cyp2c54, enhancing its arachidonic acid and linoleic acid epoxygenase activities. This influences eicosanoid synthesis, promoting the production of epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs) with vasodilatory and anti-inflammatory properties. | ||||||
Terbinafine | 91161-71-6 | sc-338609 | 100 mg | $560.00 | 1 | |
Terbinafine, an antifungal medication, indirectly activates Cyp2c54 by influencing arachidonic acid and linoleic acid metabolic processes. By inhibiting fungal ergosterol synthesis, it triggers a stress response, leading to increased expression and activity of Cyp2c54. This results in enhanced epoxygenase activities and the production of epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs) with anti-inflammatory effects. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone, a PPARγ agonist, serves as an indirect activator of Cyp2c54. By activating PPARγ, it upregulates the expression of Cyp2c54, enhancing its arachidonic acid and linoleic acid epoxygenase activities. This contributes to the modulation of eicosanoid synthesis, influencing the production of epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs) with vasodilatory and anti-inflammatory properties. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole, a proton pump inhibitor, indirectly activates Cyp2c54 by influencing arachidonic acid and linoleic acid metabolic processes. By modulating intracellular pH and oxidative stress, it triggers a stress response, leading to increased expression and activity of Cyp2c54. This results in enhanced epoxygenase activities and the production of epoxyeicosatrienoic acids (EETs) and epoxyoctadecenoic acids (EpOMEs) with anti-inflammatory effects. | ||||||