CYP2C19 Inhibitors

CYP2C19 inhibitors, belonging to the broader category of cytochrome P450 enzyme inhibitors, are a class of chemical compounds that specifically target and inhibit the activity of the cytochrome P450 2C19 enzyme. Cytochrome P450 2C19, abbreviated as CYP2C19, is a crucial enzyme found in the liver, and it plays a vital role in the metabolism of various drugs and xenobiotics. Chemically, CYP2C19 inhibitors can encompass a diverse range of compounds, including small organic molecules and synthetic drugs. These inhibitors work by binding to the active site of the CYP2C19 enzyme, interfering with its ability to metabolize substrates. This interference can result in reduced drug metabolism, leading to elevated drug concentrations in the bloodstream, which may necessitate dosage adjustments or careful monitoring when co-administering drugs that are substrates of CYP2C19.