CXX1 Inhibitors
CXX1 inhibitors encompass a variety of chemical entities that impede the protein's functionality by targeting different regulatory pathways critical for its activation and operation. For example, CXX1 is subject to regulation by phosphorylation, a common post-translational modification that modulates protein activity. Chemical entities that inhibit protein kinases responsible for this modification effectively decrease CXX1 activity. Inhibition of kinase signaling pathways such as PI3K/AKT/mTOR and MAPK/ERK, which are upstream of CXX1, results in reduced phosphorylation and subsequent deactivation of CXX1. Additionally, compounds that disrupt protein transport mechanisms also indirectly affect CXX1 by impairing its proper cellular localization and hindering its functional interactions within the cell.
Moreover, CXX1 activity can be modulated by changes in gene expression profiles influenced by the acetylation status of histones. Certain inhibitors that increase histone acetylation can suppress the expression of genes coding for activator proteins of CXX1, thus reducing its activity. Furthermore, stress-activated MAPK pathways, which may activate CXX1 through phosphorylation, can be attenuated by specific inhibitors, leading to decreased CXX1 activity. The intricate balance of calcium homeostasis is also essential for the regulation of signaling pathways associated with CXX1, and compounds that disrupt this balance can impede CXX1's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
This alkaloid acts as a potent, non-selective inhibitor of protein kinases, including those that phosphorylate CXX1. Phosphorylation is critical for CXX1 function, and inhibition of these kinases prevents CXX1 activation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, this compound increases acetylation levels, thereby affecting gene expression profiles. Enhanced acetylation may suppress expression of genes encoding proteins that activate CXX1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
This macrolide compound binds to FKBP12 and inhibits mTOR, which is upstream in signaling pathways that regulate CXX1 activity. Inhibition of mTOR signaling decreases CXX1 activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A selective inhibitor of PI3K, which is part of the PI3K/AKT/mTOR pathway. By inhibiting PI3K, this compound downregulates AKT signaling, subsequently reducing the phosphorylation and activity of CXX1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of MEK, which is involved in the MAPK/ERK pathway. By inhibiting MEK, this compound decreases ERK pathway signaling, which is necessary for the phosphorylation and activation of CXX1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This compound selectively inhibits p38 MAPK, another kinase involved in the MAPK pathway. Inhibition of p38 MAPK activity leads to reduced signaling necessary for the phosphorylation-dependent activation of CXX1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
An inhibitor of PI3K, wortmannin suppresses downstream signaling in the PI3K/AKT pathway. This results in decreased activation of kinases that control the phosphorylation state and therefore activity of CXX1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of MEK1/2, preventing the activation of ERK1/2 in the MAPK pathway. This compound thereby attenuates the signaling required for the phosphorylation and activation of CXX1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
An inhibitor of JNK, which is part of stress-activated MAPK pathways. By inhibiting JNK, it disrupts signaling pathways that lead to the activation of CXX1 through phosphorylation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
A small molecule that inhibits protein transport by blocking the exchange of GDP for GTP on ARF proteins, indirectly affecting the vesicular trafficking pathways that CXX1 might rely on for proper localization and function. | ||||||