CWF19L2 Activators
CWF19L2 engage distinct cellular mechanisms to increase the protein's activity through phosphorylation events. Forskolin, a direct activator of adenylyl cyclase, raises cyclic AMP (cAMP) levels in cells, thereby activating protein kinase A (PKA). Once active, PKA can target various proteins, including CWF19L2, for phosphorylation, which can lead to its activation. Similarly, IBMX, by inhibiting phosphodiesterases that degrade cAMP and cyclic GMP (cGMP), results in elevated levels of these cyclic nucleotides. This increase can further enhance PKA or protein kinase G (PKG) activity, which may subsequently phosphorylate and activate CWF19L2. Prostaglandin E2 (PGE2) operates through G-protein-coupled receptors to raise intracellular cAMP, facilitating PKA-mediated activation of CWF19L2. Epinephrine and Isoproterenol, both catecholamines, bind to beta-adrenergic receptors and increase cAMP levels, which in turn activate PKA, offering another route for the phosphorylation and activation of CWF19L2.
Continuing with the cascade of activation, Rolipram inhibits phosphodiesterase 4 to prevent cAMP degradation, thus sustaining PKA activity and possibly promoting CWF19L2 activation. Anisomycin, through its role as a stress-activated protein kinase activator, such as JNK, can lead to the phosphorylation of numerous proteins, including CWF19L2. Okadaic acid, a protein phosphatase inhibitor, increases phosphorylation levels within the cell, which could result in the phosphorylation and subsequent activation of CWF19L2. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which phosphorylates a variety of substrates that may include CWF19L2. Spermine, by modulating ion channel activity, can indirectly influence kinase signaling pathways to activate CWF19L2. Oleoylethanolamide interacts with PPARs, which may initiate signaling cascades leading to CWF19L2 activation. Lastly, Zaprinast, by inhibiting phosphodiesterase 5, increases cGMP levels, which could activate PKG and influence the phosphorylation status of CWF19L2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA, which can phosphorylate and thereby activate CWF19L2, assuming CWF19L2 phosphorylation leads to its activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases which degrade cAMP and cGMP. By inhibiting these enzymes, IBMX increases cAMP and cGMP levels in cells, which can enhance PKA or PKG activity that might in turn activate CWF19L2. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its G-protein-coupled receptors to increase intracellular cAMP, which activates PKA. PKA can then phosphorylate proteins including CWF19L2, leading to its activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to beta-adrenergic receptors, which can lead to an increase in cAMP and activation of PKA. PKA has the potential to phosphorylate and activate CWF19L2. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, increasing cAMP levels and activating PKA. PKA could then activate CWF19L2 by phosphorylation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, leading to an accumulation of cAMP within the cell. The increased cAMP activates PKA, which may phosphorylate and activate CWF19L2. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases like JNK. Activation of these kinases can lead to the phosphorylation and activation of various proteins, possibly including CWF19L2. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell. This could result in the enhanced phosphorylation and activation of CWF19L2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate numerous substrates, potentially including CWF19L2, resulting in its activation. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine can modulate the activity of various ion channels and indirectly influence signaling pathways. This modulation might result in changes in cellular signaling that activate CWF19L2 through phosphorylation by kinases. | ||||||