CtIP Activators
CtIP (C-terminal-binding protein-interacting protein) activators belong to a class of chemical compounds that have gained significant attention in the field of molecular biology and cellular research. CtIP itself is a crucial protein involved in DNA repair processes, specifically in the repair of DNA double-strand breaks (DSBs) through homologous recombination. Activators of CtIP play a pivotal role in modulating the activity of this protein, thereby influencing the efficiency and accuracy of DNA repair mechanisms.
These activators typically function by enhancing the recruitment and stabilization of CtIP at the sites of DNA damage. CtIP is known to be phosphorylated by various kinases, and the activation of these kinases is often mediated or facilitated by CtIP activators. This phosphorylation event is essential for CtIP's involvement in DNA repair, as it enables CtIP to interact with other key repair proteins and promote the necessary steps in homologous recombination. Moreover, CtIP activators can regulate CtIP's localization within the cell nucleus, ensuring its presence at the right place and time during DNA repair processes. By fine-tuning the activity and localization of CtIP, these chemical compounds offer a valuable tool for researchers studying DNA repair mechanisms and exploring ways to modulate these processes for various scientific purposes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate SIRT1, which can modulate pathways involved in the DNA damage response and potentially increase CtIP expression as part of these pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA, a histone deacetylase inhibitor, changes chromatin structure and can activate the transcription of numerous genes, possibly including CtIP, involved in DNA repair. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This DNA methyltransferase inhibitor may upregulate CtIP by demethylating promoter regions of genes associated with the DDR pathway. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin induces DNA damage, which may lead to upregulation of DNA repair proteins, including CtIP, as a cellular response. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
By introducing DNA strand breaks, camptothecin can stimulate the DDR pathway and potentially increase the expression of CtIP as part of the repair process. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide causes DNA damage by inhibiting topoisomerase II, which can lead to the activation of CtIP expression in an effort to initiate DNA repair mechanisms. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
It induces replication stress, which can activate the ATR pathway and may subsequently increase the expression of CtIP as part of the cellular response. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin induces cross-links in DNA that trigger the DDR, which may involve the upregulation of CtIP to deal with these lesions. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid, another histone deacetylase inhibitor, can affect gene expression profiles and potentially increase CtIP expression through epigenetic modulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane is known to affect gene expression by influencing NF-κB and Nrf2 pathways, which may intersect with pathways regulating CtIP expression. | ||||||