Cisplatin CAS: 15663-27-1
MF: Cl2H6N2Pt
Cisplatin is an apoptosis inducer and caspase-3 activator.

Cisplatin (CAS 15663-27-1)

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Sinônimo CDDP; cis-Diammineplatinum(II) dichloride
Aplicação Cisplatin is an apoptosis inducer and caspase-3 activator
Numero VAT: 15663-27-1
Privada: ≥99%
Peso Molecular: 300.05
Separar por Funcao: Cl2H6N2Pt
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Cisplatin is a potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The compound has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. Also shown to cause immunosuppression which is thought to be followed by an increase in the host immune response. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I by camptothecin (sc-200871). Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin (sc-202093) and oxaliplatin (sc-202270), that form DNA adducts resulting in apoptosis; however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.


Referencias

1. Bagasra, O., et al. 1985. Cancer Immunol. Immunother. 19: 142-147. PMID: 3157438
2. Bose, R.N. 2002. Mini Rev Med Chem. 2: 103-111. PMID: 12370072
3. Siddik, Z.H. 2003. Oncogene. 22: 7265-7279. PMID: 14576837
4. van Waardenburg, R.C., et al. 2004. J. Biol. Chem. 279: 54502-54509. PMID: 15471886

Aparência :
Powder or crystalline
Estado físico :
Solid
envie :
Soluble in water (0.25 g/100ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMF (16 mg/ml).
Manutencao :
Store at room temperature
Ponto de fusão :
270° C
Densidade :
3.74 g/cm3
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
RTECS :
TP2450000
PubChem CID :
441203
Indice de produtos :
14: 2317
Numero de FAX :
MFCD00011623
Numero de FAX :
239-733-8
SMILES :
N.N.Cl[Pt+2]Cl

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Cisplatin  Citacoes dos Produtos

Visualizar com outras pessoas usaram Cisplatin. Clique em PubMed para ver .

Citações 1 para 10 de 43 total

PMID: # 31374291  Li, X.|He, S.|Tian, Y.|Weiss, RM.|Martin, DT.| et al. 2019. Cell. Signal. 63: 109381.

PMID: # 29620162  Yang, X. et al. 2018. Int. J. Oncol. 52: 2021-2030.

PMID: # 29106395  2018. Lab. Invest. 98: 63-78.

PMID: # 28265008  Liu, CW. et al. 2017. Mol. Cancer Ther. 16: 1421-1434.

PMID: # 28692634  Westhoff, GL.|Chen, Y.|Teng, NNH.| et al. 2017. Int. J. Gynecol. Cancer. 27: 1602-1609.

PMID: # 29267289  Chen, Y. et al. 2017. PLoS ONE. 12: e0187222.

PMID: # 29132253  İnci, D. et al. 2017. J. Biomol. Struct. Dyn. 1-24.

PMID: # 28567715  Zhao, H. et al. 2017. Cell Oncol (Dordr). 40: 357-365.

PMID: # 28602975  Kollareddy, M.|Sherrard, A.|Park, JH.|Szemes, M.|Gallacher, K.|Melegh, Z.|Oltean, S.|Michaelis, M.|Cinatl, J.|Kaidi, A.|Malik, K.| et al. 2017. Cancer Lett. 403: 74-85.

PMID: # 28339648  Pendergraft, SS. et al. 2017. Biol. Reprod. 96: 720-732.

Citações 1 para 10 de 43 total
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