CSN4 Inhibitors
CSN4 inhibitors are a class of compounds that specifically target **CSN4**, a subunit of the COP9 signalosome complex. This complex plays a crucial role in various cellular processes, including protein degradation, signal transduction, and the regulation of gene expression. CSN4 itself is involved in the modification of cullin-RING E3 ligases, which are essential for the ubiquitin-proteasome pathway that regulates protein turnover. By inhibiting CSN4, these compounds disrupt the normal functioning of the COP9 signalosome, leading to alterations in the stability and activity of numerous proteins, which can affect a wide range of cellular functions.
The exploration of CSN4 inhibitors enables researchers to investigate the downstream effects of disrupted signalosome activity on cellular homeostasis and metabolic pathways. By manipulating CSN4 function, scientists can study how changes in protein stability influence critical processes such as cell cycle progression, apoptosis, and stress responses. Furthermore, these inhibitors provide valuable tools for dissecting the molecular mechanisms underlying signal transduction pathways, particularly those involving the cullin-RING ligases. Through such studies, CSN4 inhibitors contribute to a deeper understanding of the roles that ubiquitination and protein degradation play in maintaining cellular integrity and how their dysregulation may lead to various biological phenomena. This chemical class, therefore, serves as a vital resource for advancing the knowledge of fundamental cellular processes governed by the COP9 signalosome.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide may downregulate CSN4 expression by inhibiting the activity of transcription factors essential for CSN4 gene transcription or by suppressing RNA polymerase II-mediated mRNA synthesis. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D can decrease CSN4 mRNA transcription by intercalating into DNA and obstructing the elongation phase of RNA synthesis, leading to a reduction in CSN4 mRNA levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting the mTOR pathway, Rapamycin may decrease the translation of CSN4 mRNA, leading to lower production of the CSN4 protein. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can lead to DNA demethylation, which in some cases results in transcriptional silencing, thereby potentially decreasing CSN4 expression levels. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 inhibits proteasome activity, which could lead to the accumulation of specific transcriptional repressors that would otherwise degrade; this accumulation may contribute to the reduced expression of CSN4. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $182.00 $661.00 | 10 | |
Chetomin disrupts the HIF-1 pathway, which may result in the decreased transcription of CSN4 if CSN4 is a gene target of HIF-1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may downregulate CSN4 expression by inhibiting NF-kB signaling, which could be involved in the transcriptional activation of CSN4. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may downregulate CSN4 expression through activation of sirtuins that deacetylate histones associated with the CSN4 gene, leading to tighter chromatin structure and reduced transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor, resulting in hyperacetylation of histones, which could lead to the reduced expression of CSN4 by altering the accessibility of transcription machinery to the CSN4 gene locus. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This compound might decrease CSN4 expression by altering DNA methylation patterns or modifying histones associated with the CSN4 gene, thereby changing the gene's transcriptional activity. | ||||||